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Subsynaptic Distribution, Lipid Raft Targeting and G Protein-Dependent Signalling of the Type 1 Cannabinoid Receptor in Synaptosomes from the Mouse Hippocampus and Frontal Cortex
(MDPI, 2021-11-16)
Numerous studies have investigated the roles of the type 1 cannabinoid receptor (CB1) in glutamatergic and GABAergic neurons. Here, we used the cell-type-specific CB1 rescue model in mice to gain insight into the organizational ...
Cannabis use selectively modulates circulating biomarkers in the blood of schizophrenia patients
(Wiley, 2022-11)
Cannabis use disorder is frequent in schizophrenia patients, and it is associated with an earlier age of onset and poor schizophrenia prognosis. Serotonin 2A receptors (5-HT2AR) have been involved in psychosis and, like ...
Alginate Bead Biosystem for the Determination of Lactate in Sweat Using Image Analysis
(MDPI, 2021-10-09)
Lactate is present in sweat at high concentrations, being a metabolite of high interest in sport science and medicine. Therefore, the potential to determine lactate concentrations in physiological fluids, at the point of ...
From target analysis to suspect and non-target screening of endocrine-disrupting compounds in human urine
(Springer, 2022)
[EN] In the present work, a target analysis method for simultaneously determining 24 diverse endocrine-disrupting compounds (EDCs) in urine (benzophenones, bisphenols, parabens, phthalates and antibacterials) was developed. ...
Elemental imaging approach to assess the ability of subaerial biofilms growing on constructions located in tropical climates as potential biomonitors of atmospheric heavy metals pollution
(Elsevier, 2022-10-06)
Over the last decades, the concern about air pollution has increased significantly, especially in urban areas. Active sampling of air pollutants requires specific instrumentation not always available in all the laboratories. ...
Characterization of the contamination fingerprint of wastewater treatment plant effluents in the Henares River Basin (central Spain) based on target and suspect screening analysis
(Elsevier, 2022-02-01)
The interest in contaminants of emerging concern (CECs) has increased lately due to their continued emission and potential ecotoxicological hazards. Wastewater treatment plants (WWTPs) are generally not capable of eliminating ...
TiO2 Nanotubes Alginate Hydrogel Scaffold for Rapid Sensing of Sweat Biomarkers: Lactate and Glucose
(American Chemical Society, 2021-08-11)
Versatile sensing matrixes are essential for the development of enzyme-immobilized optical biosensors. A novel three-dimensional titanium dioxide nanotubes/alginate hydrogel scaffold is proposed for the detection of sweat ...
Integrated biological response to environmentally-relevant concentration of amitriptyline in Sparus aurata
(Elsevier, 2021-11)
[EN]Amitriptyline (AMI) is a commonly tricyclic antidepressant to treat depression, anxiety, and other conditions. Like many other pharmaceuticals, AMI and its by-products are incompletely removed during wastewater treatment ...
Multi-Target Analysis and Suspect Screening of Xenobiotics in Milk by UHPLC-HRMS/MS
(MDPI, 2021-01-26)
The development of suspect or non-target screening methods to detect xenobiotics in biological fluids is essential to properly understand the exposome and assess its adverse health effects on humans. In order to fulfil ...
Source identification of amphetamine-like stimulants in Spanish wastewater through enantiomeric profiling
(Elsevier, 2021-11-01)
[EN]Amphetamine (AMP), methamphetamine (MAMP) and 3,4-methylenedioxymethamphetamine (MDMA) occur in wastewater not only as a result of illicit consumption, but also, in some cases, from prescription drug use or by direct ...