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Contribution of the GABAergic System to Non-Motor Manifestations in Premotor and Early Stages of Parkinson’s Disease
(Frontiers Media, 2019-10-30)
Non-motor symptoms are common in Parkinson's disease (PD) and they represent a major source of disease burden. Several non-motor manifestations, such as rapid eye movement sleep behavior disorder, olfactory loss, ...
Eppur non si muove: Experimental evidence for the Unaccusative Hypothesis and distinct ɸ-feature processing in Basque
(Ubiquity Press, 2019-11)
The Unaccusative Hypothesis (UH) has been extensively studied in linguistics, but, to date, it has not been tested by means of ERPs. The present study aimed to experimentally test the UH hypothesis in Basque and determine ...
Decline in fertility induced by economic recession in Spain
(2019-10)
OBJECTIVE: To describe trends in fertility in Spain before (pre-recession; 1998-2008) and during (recession period; 2009-2013) the economic crisis of 2008, taking into account women's age and regional unemployment in ...
Linking Biophysical and Economic Assessments of Ecosystem Services for a Social-Ecological Approach to Conservation Planning: Application in a Biosphere Reserve (Biscay, Spain)
(MDPI, 2019-06-01)
The search for a balance between nature conservation and sustainable development remains a scientific and spatial planning challenge. In social-ecological systems based on traditional rural activities and associated with ...
Membrane Permeabilization by Pore-Forming RTX Toxins: What Kind of Lesions Do These Toxins Form?
(MDPI, 2019-06-18)
Pore-forming toxins (PFTs) form nanoscale pores across target membranes causing cell death. The pore-forming cytolysins of the RTX (repeats in toxin) family belong to a steadily increasing family of proteins characterized ...
Serotonin 5-HT2A receptor expression and functionality in postmortem frontal cortex of subjects with schizophrenia: Selective biased agonism via Gαi1-proteins
(Elsevier, 2019-12)
Serotonin 5-HT2A receptors (5-HT(2A)Rs) have been implicated in schizophrenia. However, postmortem studies on 5-HT(2A)Rs expression and functionality in schizophrenia are scarce. The 5-HT2AR mRNA and immunoreactive protein ...
Intramolecular Palladium(II)-catalyzed 6-endo C-H alkenylation directed by the remote N-protecting group. Mechanistic insight and application to the synthesis of dihydroquinolines
(American Chemical Society, 2019-12-30)
A protocol for the Pd(II)-catalyzed C-H alkenylation reaction of substituted N-allylanilines
via an unusual 6-endo process has been developed. A DFT study of the mechanistic pathway has shown
that the coordination of the ...
Peculiar magnetocaloric properties and critical behavior in antiferromagnetic Tb3Ni with complex magnetic structure
(Elsevier, 2019-08-12)
A study on the magnetocaloric properties of a Tb3Ni single crystal (which crystallizes in the orthorhombic Pnma space group) has been undertaken and combined with the study of the character and critical behavior of its ...
Study of the magnetocaloric effect in intermetallics RTX (R = Nd, Gd; T = Sc, Ti ; X = Si, Ge)
(Elsevier, 2019-05-02)
A detailed study of the magnetocaloric properties of six compounds of the intermetallic family RTX (R = Nd, Gd; T = Sc, Ti ; X = Si, Ge) has been undertaken: NdScSi, NdScGe, GdScSi, GdScGe, GdSc(Si0.5Ge0.5) and Gd(Sc0.5Ti0.5)Ge. ...
Carbopalladation/Suzuki Coupling Cascade for the Generation of Quaternary Centers. Access to Pyrrolo[1,2-b]isoquinolines
(American Chemical Society, 2019-07-29)
A convergent route to pyrrolo[1,2-b]isoquinolines with a quaternary center at C-10 has been
developed, that implies a sequential Pd(0)-catalyzed carbopalladation followed by cross-coupling
reaction with boronic acids. ...