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Optimization of the Bioactivation of Isoflavones in Soymilk by Lactic Acid Bacteria
(MDPI, 2021-05-28)
Soybeans and soy-based products contain isoflavones which can be used for nutraceutical and medical applications. In soybeans and in unfermented soy foods, isoflavones are normally present as glycosides. Isoflavone glycosides ...
Phosphatidic Acid Stimulates Myoblast Proliferation through Interaction with LPA1 and LPA2 Receptors
(MDPI, 2021-02-01)
Phosphatidic acid (PA) is a bioactive phospholipid capable of regulating key biological functions, including neutrophil respiratory burst, chemotaxis, or cell growth and differentiation. However, the mechanisms whereby PA ...
VLP-Based Vaccines as a Suitable Technology to Target Trypanosomatid Diseases
(MDPI, 2021-03-05)
Research on vaccines against trypanosomatids, a family of protozoa that cause neglected tropical diseases, such as Chagas disease, leishmaniasis, and sleeping sickness, is a current need. Today, according to modern ...
Ceramide Metabolism and Parkinson’s Disease—Therapeutic Targets
(MDPI, 2021-06-25)
Ceramide is a bioactive sphingolipid involved in numerous cellular processes. In addition to being the precursor of complex sphingolipids, ceramides can act as second messengers, especially when they are generated at the ...
Virion Structure and In Vitro Genome Release Mechanism of Dicistrovirus Kashmir Bee Virus
(American Society For Microbiology, 2021-06)
Infections with Kashmir bee virus (KBV) are lethal for honeybees and have been associated with colony collapse disorder. KBV and closely related viruses contribute to the ongoing decline in the number of honeybee colonies ...
Quantification of Biomarker Functionality Predicts Patient Outcomes
(Springer Nature, 2021-05-11)
Implementation of a quantitative molecular imaging method (iFRET), which determines receptor–ligand interactions, has led to the finding that patients with a low extent of PD-1/PD-L1 interaction in metastatic NSCLC, and ...
Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts
(Elsevier, 2021-10)
BACKGROUND & AIMS: Colorectal cancer (CRC) shows variable response to immune checkpoint blockade, which can only partially be explained by high tumor mutational burden (TMB). We conducted an integrated study of the cancer ...
In Vitro Cellular Uptake Studies of Self-Assembled Fluorinated Nanoparticles Labelled with Antibodies
(MDPI, 2021-07-24)
Nanoparticles (NPs) functionalized with antibodies (Abs) on their surface are used in a wide range of bioapplications. Whereas the attachment of antibodies to single NPs to trigger the internalization in cells via ...
Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA
(American Association for the Advancement of Science, 2021-10)
[EN]Glycolipids are prominent components of bacterial membranes that play critical roles not only in maintaining the structural integrity of the cell but also in modulating host-pathogen interactions. PatA is an essential ...
FORTIS: a Live-Cell Assay to Monitor AMPA Receptors Using pH-Sensitive Fluorescence Tags
(Nature, 2021-05-27)
The real-time live fluorescent monitoring of surface AMPA receptors (AMPARs) could open new opportunities for drug
discovery and phenotypic screening concerning neuropsychiatric disorders. We have developed FORTIS, a tool ...