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The triacylglycerol, hydroxytriolein, inhibits triple negative mammary breast cancer cell proliferation through a mechanism dependent on dihydroceramide and Akt
(Impact Journals, 2019-04-02)
The plasma membrane is an attractive target for new anticancer drugs, not
least because regulating its lipid structure can control multiple signaling pathways
involved in cancer cell proliferation, differentiation and ...
Accumulated Bending Energy Elicits Neutral Sphingomyelinase Activity in Human Red Blood Cells
(Elservier, 2012-05-02)
[EN] We propose that accumulated membrane bending energy elicits a neutral sphingomyelinase (SMase) activity in human erythrocytes. Membrane bending was achieved by osmotic or chemical processes, and SMase activity was ...
The effect of hydroxylated fatty acid-containing phospholipids in the remodeling of lipid membranes
(Elsevier B.V., 2014-01-24)
The synthetic fatty acid 2-hydroxyoleic acid (2OHOA) is an antitumor drug that regulates membrane lipid composition and structure. An important effect of this drug is the restoration of sphingomyelin (SM) levels in cancer ...
LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs
(Taylor & Francis, 2022-12)
Externalization of the phospholipid cardiolipin (CL) to the outer mitochondrial membrane has been proposed to act as a mitophagy trigger. CL would act as a signal for binding the LC3 macroauto-phagy/autophagy proteins. As ...
Effect of ATG12–ATG5-ATG16L1 autophagy E3-like complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion
(Springer, 2023-02)
In macroautophagy, the autophagosome (AP) engulfs portions of cytoplasm to allow their lysosomal degradation. AP formation in humans requires the concerted action of the ATG12 and LC3/GABARAP conjugation systems. The ...
Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia
(Nature Research, 2017-10-24)
Nucleophosmin (NPM) is a nucleolar protein involved in ribosome assembly and cell homeostasis. Mutations in the C-terminal domain of NPM that impair native folding and localization are associated with acute myeloid leukemia ...
Partitioning of liquid-ordered/liquid-disordered membrane microdomains induced by the fluidifying effect of 2-hydroxylated fatty acid derivatives
(2013-06-18)
[EN] Cellular functions are usually associated with the activity of proteins and nucleic acids. Recent studies have shown that lipids modulate the localization and activity of key membrane-associated signal transduction ...
Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge
(Nature Publishing, 2017-11-15)
Specific protein-lipid interactions lead to a gradual recruitment of AuTophaGy-related (ATG) proteins to the nascent membrane during autophagosome (AP) formation. ATG3, a key protein in the movement of LC3 towards the ...
Triacylglycerol mimetics regulate membrane interactions of glycogen branching enzyme: implications for therapy
(Elsevier, 2017-06-19)
Adult polyglucosan body disease (APBD) is a neurological disorder characterized by adult-onset neurogenic bladder, spasticity, weakness, and sensory loss. The disease is caused by aberrant glycogen branching enzyme (GBE) ...
Pb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells
(Nature Publishing, 2018-05-10)
The mechanisms of Pb(II) toxicity have been studied in human red blood cells using confocal microscopy, immunolabeling, fluorescence-activated cell sorting and atomic force microscopy. The process follows a sequence of ...