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Serotonin 5-HT2A receptor expression and functionality in postmortem frontal cortex of subjects with schizophrenia: Selective biased agonism via Gαi1-proteins
(Elsevier, 2019-12)
Serotonin 5-HT2A receptors (5-HT(2A)Rs) have been implicated in schizophrenia. However, postmortem studies on 5-HT(2A)Rs expression and functionality in schizophrenia are scarce. The 5-HT2AR mRNA and immunoreactive protein ...
Anatomical location of LPA1 activation and LPA phospholipid precursors in rodent and human brain
(John Wiley & Sons, 2015-04-10)
El ácido lisofosfatídico (LPA) es una molécula de señalización que se une a seis receptores acoplados a proteínas G conocidos: LPA1 -LPA6 . El LPA evoca varias respuestas en el SNC, entre ellas el desarrollo y plegamiento ...
Anatomical distribution of lipids in human brain cortex by imaging mass spectrometry
(Springer Verlag, 2011-01-28)
[ES] Las imágenes de masa molecular de los tejidos estarán sesgadas si las diferencias en las propiedades fisicoquímicas del microentorno afectan a la intensidad de los espectros. Para abordar esta cuestión, hemos realizado ...
Effects of adult enriched environment on cognition, hippocampal- prefrontal plasticity and NMDAR subunit expression in MK-801- induced schizophrenia model
(Elsevier, 2019-05-01)
Schizophrenia is a mental disorder characterized by psychosis, negative symptoms and cognitive impairment. Cognitive deficits are enduring and represent the most disabling symptom but are currently poorly treated. N-methyl ...
Effects of galanin subchronic treatment on memory and muscarinic receptors.
(Elsevier, 2015-05-07)
Las vías colinérgicas, que se originan en el prosencéfalo basal y son responsables del control de diferentes procesos cognitivos como el aprendizaje y la memoria también están reguladas por algunos neuropéptidos. Uno de ...
In vitro pharmacodynamic modelling of anidulafungin against Candida spp.
(Elsevier, 2016-03)
[ES] El objetivo de este estudio fue ajustar los datos estáticos de muerte temporal in vitro de anidulafungina de nueve cepas de Candida con un modelo farmacodinámico (PD) para describir la actividad antifúngica de este ...
Postantifungal Effect of Micafungin against the Species Complexes of Candida albicans and Candida parapsilosis
(Public Library Science, 2015-07-13)
Micafungin is an effective antifungal agent useful for the therapy of invasive candidiasis. Candida albicans is the most common cause of invasive candidiasis; however, infections due to non-C. albicans species, such as ...
Cellular neurochemical characterization and subcellular localization of Phospholipase C-β1 in rat brain
(Elsevier, 2012-10-11)
The present study describes a complete and detailed neuroanatomical distribution map of the phospholipase C beta1 (PLCβ1) isoform along the adult rat neuraxis, and defines the phenotype of cells expressing PLCβ1, along ...
Buspirone anti-dyskinetic effect is correlated with temporal normalization of dysregulated striatal DRD1 signalling in L-DOPA-treated rats
(Elsevier, 2014-04)
Dopamine replacement with l-DOPA is the most effective therapy in Parkinson's disease. However, with chronic treatment, half of the patients develop an abnormal motor response including dyskinesias. The specific molecular ...
Validation of an LC-ESI-MS/MS for the quantitation of phosphodiesterase-5 inhibitors and their main metabolites in rat serum and brain tissue samples.
(Elsevier, 2012-105-1)
This work proposes a liquid chromatography-electrospray ionization ion trap mass spectrometry (LC-ESI-ITMS) method, for the quantification of sildenafil (SDF), tadalafil (TDF) and vardenafil (VDF) and their metabolites ...