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Graphene oxide enhances alginate encapsulated cells viability and functionality while not affecting the foreign body response
(Taylor & Francis, 2018-05-21)
The combination of protein-coated graphene oxide (GO) and microencapsulation technology has moved a step forward in the challenge of improving long-term alginate encapsulated cell survival and sustainable therapeutic protein ...
3D Printed Porous Polyamide Macrocapsule Combined with Alginate Microcapsules for Safer Cell-Based Therapies
(Nature Publishing Group, 2018-05-31)
Cell microencapsulation is an attractive strategy for cell-based therapies that allows the implantation of genetically engineered cells and the continuous delivery of de novo produced therapeutic products. However, the ...
The role of osmolarity adjusting agents in the regulation of encapsulated cell behavior to provide a safer and more predictable delivery of therapeutics
(Taylor & Francis, 2017-10-27)
Transplantation of cells within alginate microspheres has been extensively studied for sustained drug delivery. However, the lack of control over cell behavior represents a major concern regarding the efficacy and the ...
An Overview on the Field of Micro- and Nanotechnologies for Synthetic Peptide-Based Vaccines
(Hindawi Publishing Corporation, 2011)
The development of synthetic peptide-based vaccines has many advantages in comparison with vaccines based on live attenuated organisms, inactivated or killed organism, or toxins. Peptide-based vaccines cannot revert to a ...
BSA- and Elastin-Coated GO, but Not Collagen-Coated GO, Enhance the Biological Performance of Alginate Hydrogels
(MDPI, 2020-06-11)
The use of embedded cells within alginate matrices is a developing technique with great clinical applications in cell-based therapies. However, one feature that needs additional investigation is the improvement of ...
Overcoming the Inflammatory Stage of Non-Healing Wounds: In Vitro Mechanism of Action of Negatively Charged Microspheres (NCMs)
(MDPI, 2020-06-03)
Negatively charged microspheres (NCMs) represent a new therapeutic approach for wound healing since recent clinical trials have shown NCM efficacy in the recovery of hard-to-heal wounds that tend to stay in the inflammatory ...
Assessment of Soybean Oil Oxidative Stability from Rapid Analysis of its Minor Component Profile
(MDPI, 2020-09-21)
The minor components of vegetable oils are important for their oxidative stability. In order to know to what extent they can influence oil behaviour under oxidative conditions, two commercial soybean oils, one virgin and ...
Increased antiparkinson efficacy of the combined administration of VEGF- and GDNF-loaded nanospheres in a partial lesion model of Parkinson's disease
(Dove Medical Press, 2014)
Current research efforts are focused on the application of growth factors, such as glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), as neuroregenerative approaches that will ...
Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier
(Elsevier, 2013)
[EN] The aims of this work were (i) to evaluate the potential of nanostructured lipid carriers (NLCs) as a tool to 24
enhance the oral bioavailability of poorly soluble compounds using saquinavir (SQV), a BCS class IV ...
Dextran and protamine-based solid lipid nanoparticles as potential vectors for the treatment of X-linked juvenile retinoschisis
(Mary Ann Liebert, Inc., 2012-04)
[EN]The goal of the present study was to analyze the potential application of nonviral vectors based on solid lipid
nanoparticles (SLN) for the treatment of ocular diseases by gene therapy, specifically X-linked juvenile ...