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Nobiletin Enhances the Development and Quality of Bovine Embryos In Vitro During Two Key Periods of Embryonic Genome Activation
(Nature, 2021-06-03)
In vitro culture can alter the development and quality of bovine embryos. Therefore, we aimed to evaluate whether nobiletin supplementation during EGA improves embryonic development and blastocyst quality and if it affects ...
Phosphorylation and Stabilization of PIN1 by JNK Promote Intrahepatic Cholangiocarcinoma Growth
(American Association for the Study of Liver Diseases, 2021-11)
Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive type of liver cancer in urgent need of treatment options. Aberrant activation of the c-Jun N-terminal kinase (JNK) pathway is a key feature ...
Liver metastases of intrahepatic Cholangiocarcinoma: implications for an updated staging system
(Wiley, 2021-06-18)
[EN] BACKGROUND AND AIMS: Intrahepatic cholangiocarcinoma
(iCCA) with liver metastases is perceived to have a
poor prognosis, but the American Joint Committee on Cancer
(AJCC) classifies them as early stage in the absence ...
Testing the Multiple Pathways of Residential Greenness to Pregnancy Outcomes Model in a Sample of Pregnant Women in the Metropolitan Area of Donostia-San Sebastián
(MDPI, 2020-06-23)
Residential greenness may positively impact diverse human health indicators through the reduction of air pollution, the improvement of psychological health, and the promotion of physical activity. Previous studies indicate ...
The relative age effect in young athletes: a countywide analysis of 9–14-year-old participants in all competitive sports
(Public Library of Science, 2021-07-16)
[EN] The relative age effect (RAE) has primarily been investigated in male athletes involved in
popular sports and high-level competitions. However, occurrence of RAE in other types of
sports at the grassroots level, ...
Altered expression of fibroblast activation protein-α (FAP) in colorectal adenoma-carcinoma sequence and in lymph node and liver metastases
(Impact Journals, 2020-06-15)
Colorectal cancer (CRC) is a major health problem in elderly people because of its high incidence and high mortality rate. Despite early screening programs, more than half of CRC patients are diagnosed at advanced stages. ...
The Activation of Prothrombin Seems to Play an Earlier Role than the Complement System in the Progression of Colorectal Cancer: A Mass Spectrometry Evaluation
(MDPI, 2020-12-11)
Colorectal cancer (CRC) is the second cause of death in men and the third in women. This work deals with the study of the low molecular weight protein fraction of sera from patients who underwent surgery for CRC and who ...
(Pro)renin Receptor Is a Novel Independent Prognostic Marker in Invasive Urothelial Carcinoma of the Bladder
(MDPI, 2021-11-11)
(Pro)renin receptor (PRR) is being investigated in several malignancies as it activates pathogenic pathways that contribute to cell proliferation, immunosuppressive microenvironments, and acquisition of aggressive neoplastic ...
Soluble PD-L1 Is an Independent Prognostic Factor in Clear Cell Renal Cell Carcinoma
(MDPI, 2021-02-07)
(1). Background: Immunohistochemical (IHC) evaluation of programmed death-1 (PD-1) and its ligand (PD-L1) is being used to evaluate advanced malignancies with potential response to immune checkpoint inhibitors. We evaluated ...
Clinical Implications of (Pro)renin Receptor (PRR) Expression in Renal Tumours
(MDPI, 2021-02-10)
(1) Background: Renal cancer is one of the most frequent malignancies in Western countries, with an unpredictable clinical outcome, partly due to its high heterogeneity and the scarcity of reliable biomarkers of tumour ...