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Targeting E2F Sensitizes Prostate Cancer Cells to Drug-Induced Replication Stress by Promoting Unscheduled CDK1 Activity
(MDPI, 2022-10-10)
E2F1/E2F2 expression correlates with malignancy in prostate cancer (PCa), but its functional significance remains unresolved. To define the mechanisms governed by E2F in PCa, we analyzed the contribution of E2F target genes ...
Acoustophoretic trapping of particles by bubbles in microfluidics
(Frontiers Media, 2023-01)
We present in this paper a simple method to produce strategic acoustic particle capture sites in microfluidic channels in a controlled way. Air bubbles are intermittently injected into a micro-capillary with rectangular ...
Nonionic Surfactants can Modify the Thermal Stability of Globular and Membrane Proteins Interfering with the Thermal Proteome Profiling Principles to Identify Protein Targets
(American Chemical Society, 2023-02)
The membrane proteins are essential targets for understanding cellular function. The unbiased identification of membrane protein targets is still the bottleneck for a system-level understanding of cellular response to ...
Self-assembled three-dimensional hydrogels based on graphene derivatives and cerium oxide nanoparticles: scaffolds for co-culture of oligodendrocytes and neurons derived from neural stem cells
(American Chemical Society, 2023-03)
Stem cell-based therapies have shown promising results for the regeneration of the nervous system. However, the survival and integration of the stem cells in the neural circuitry is suboptimal and might compromise the ...
Germline Gene Editing: The Gender Issues
(Cambridge University Press, 2023-04)
Human germline gene editing constitutes an extremely promising technology; at the same time, however, it raises remarkable ethical, legal, and social issues. Although many of these issues have been largely explored by the ...
Intelligent Sitting Posture Classifier for Wheelchair Users
(IEEE, 2023)
In recent years, there has been growing interest in postural monitoring while seated, thus preventing the appearance of ulcers and musculoskeletal problems in the long term. To date, postural control has been carried out ...
Targeting mTOR as a Therapeutic Approach in Medulloblastoma
(MDPI, 2018-07)
Mechanistic target of rapamycin (mTOR) is a master signaling pathway that regulates organismal growth and homeostasis, because of its implication in protein and lipid synthesis, and in the control of the cell cycle and the ...
Redox regulation of KV7 channels through EF3 hand of calmodulin
(eLife Sciences, 2023-01)
Neuronal KV7 channels, important regulators of cell excitability, are among the most sensitive proteins to reactive oxygen species. The S2S3 linker of the voltage sensor was reported as a site-mediating redox modulation ...
The Role of Sperm Membrane Potential and Ion Channels in Regulating Sperm Function
(MDPI, 2023-04-10)
During the last seventy years, studies on mammalian sperm cells have demonstrated the essential role of capacitation, hyperactivation and the acrosome reaction in the acquisition of fertilization ability. These studies ...
Mortality Risks after Two Years in Frail and Pre-Frail Older Adults Admitted to Hospital
(MDPI, 2023-04-24)
Background: Frailty is characterized by a progressive decline in the physiological functions of multiple body systems that lead to a more vulnerable condition, which is prone to the development of various adverse events, ...