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Mortality Risks after Two Years in Frail and Pre-Frail Older Adults Admitted to Hospital
(MDPI, 2023-04-24)
Background: Frailty is characterized by a progressive decline in the physiological functions of multiple body systems that lead to a more vulnerable condition, which is prone to the development of various adverse events, ...
Notch and Wnt Signaling Modulation to Enhance DPSC Stemness and Therapeutic Potential
(MDPI, 2023-04-17)
The Dental Pulp of permanent human teeth is home to stem cells with remarkable multilineage differentiation ability: human Dental Pulp Stem Cells (DPSCs). These cells display a very notorious expression of pluripotency ...
Sensorized Tip for Monitoring People with Multiple Sclerosis that Require Assistive Devices for Walking
(MDPI, 2020-08-03)
Multiple Sclerosis (MS) is a neurological degenerative disease with high impact on our society. In order to mitigate its effects, proper rehabilitation therapy is mandatory, in which individualisation is a key factor. ...
The Nutritional Status of Long-Term Institutionalized Older Adults Is Associated with Functional Status, Physical Performance and Activity, and Frailty
(MDPI, 2021-10-22)
Among older adults living in long-term nursing homes (LTNHs), maintaining an adequate functional status and independence is a challenge. Whilst a poor nutritional status is a potential risk factor for a decreased function ...
Wnt-3a Induces Epigenetic Remodeling in Human Dental Pulp Stem Cells
(MDPI, 2020-03-07)
Dental pulp stem cells (DPSCs) from adult teeth show the expression of a very complete repertoire of stem pluripotency core factors and a high plasticity for cell reprogramming. Canonical Wnt and Notch signaling pathways ...
A preliminary analysis of gait performance of patients with multiple sclerosis using a sensorized crutch tip
(Elsevier, 2020-07-17)
The quality of life and functional mobility of patients with Multiple Sclerosis (MS) can significantly improve with exercise and a rehabilitation therapy adjusted to the needs of each patient. The assessment of gait and ...
Autocrine regulation of human sperm motility by tachykinins
(BioMed Central, 2010)
Background
We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa.
Methods
Freshly ejaculated semen was collected from ...
The Voltage-Gated Sodium Channel Na(v)1.8 Is Expressed in Human Sperm
(Public Library of Science, 2013-09)
The role of Na+ fluxes through voltage-gated sodium channels in the regulation of sperm cell function remains poorly understood. Previously, we reported that several genes encoding voltage-gated Na+ channels were expressed ...
An Epilepsy-Causing Mutation Leads to Co-Translational Misfolding of the Kv7.2 Channel
(Springer, 2021-05-21)
BACKGROUND: The amino acid sequence of proteins generally carries all the necessary information for acquisition of native conformations, but the vectorial nature of translation can additionally determine the folding outcome. ...
The Multifunctional Role of SPANX-A/D Protein Subfamily in the Promotion of Pro-Tumoural Processes in Human Melanoma
(Nature, 2021-02-11)
Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes encode a protein family (SPANX-A, -B, -C and -D), whose expression is limited to the testis and spermatozoa in normal tissues and various ...