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Now showing items 201-210 of 233
Biluzik elurretan.
(Elhuyar, 2021-07-21)
2021. urte hau historikoa izaten ari da, ez bakarrik COVID-19aren pandemiagatik eta AEBko Kapitolioari eraso egin ziotelako, baita Filomena deituriko ekaitz gogorrak eragindako muturreko hotz-boladagatik ere. Zer pentsatuko ...
CaMKII modulates the cardiac transient outward K+ current through their association in non-caveolar membrane rafts
(University of Duisburg-Essen, 2020-01-15)
Background/aims: To test whether the physiological regulation of the cardiac Kv4 channels by the Ca2+/calmodulin-dependent protein kinase II (CaMKII) is restricted to lipid rafts and whether the interactions observed in ...
Deciphering the roles of triiodothyronine (T3) and thyroid stimulating hormone (TSH) on cardiac electrical remodeling in clinical and experimental hypothyroidism
(Springer, 2024-02)
Hypothyroidism is the most frequent endocrine pathology. Although clinical or overt hypothyroidism has been traditionally associated to low T3 / T4 and high thyrotropin (TSH) circulating levels, other forms exist such as ...
Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1
(Springer, 2021-11)
Specific and selective anti-CB1 antibodies are among the most powerful research tools to unravel the complex biological processes mediated by the CB1 receptor in both physiological and pathological conditions. However, low ...
p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1
(Public Library Science, 2021-11-10)
[EN]During the first weeks of postnatal heart development, cardiomyocytes undergo a major adaptive metabolic shift from glycolytic energy production to fatty acid oxidation. This metabolic change is contemporaneous to the ...
Metformin Reduces Potassium Currents and Prolongs Repolarization in Non-Diabetic Heart
(MDPI, 2022-05-27)
Metformin is the first choice drug for the treatment of type 2 diabetes due to positive results in reducing hyperglycaemia and insulin resistance. However, diabetic patients have higher risk of ventricular arrhythmia and ...
TensioBot: a chatbot assistant for self-managed in-house blood pressure checking
(Springer, 2021-03-15)
[ES] Tensiobot es un chatbot de apoyo asistencial, cuyo objetivo esayudar a los pacientes a realizar sus mediciones de tensión arterial en domicilio. Nuestros resultados muestran que el cumplimiento del programa de control ...
The conserved helix C region in the superfamily of interferon-gamma /interleukin-10-related cytokines corresponds to a high-affinity binding site for the HSP70 chaperone DnaK.
(Elsevier, 2002-07-12)
HSP70 chaperones mediate protein folding by ATP-dependent interaction with short linear peptide segments that are exposed on unfolded proteins. The mode of action of the Escherichia coli homolog DnaK is representative of ...
Inhibition of secretion of interleukin (IL)-12/IL-23 family cytokines by 4-trifluoromethyl-celecoxib is coupled to degradation via the endoplasmic reticulum stress protein HERP
(American Society for Biochemistry and Molecular Biology, Inc, 2010-03-05)
Interleukin-12 (IL-12), p80, and IL-23 are structurally related cytokines sharing a p40 subunit. We have recently demonstrated that celecoxib and its COX-2-independent analogue 4-trifluoromethyl-celecoxib (TFM-C) inhibit ...
Up-regulation of CB1 Cannabinoid Receptors Located at Glutamatergic Terminals in the Medial Prefrontal Cortex of the Obese Zucker Rat.
(Frontiers Media, 2022-10-18)
The present study describes a detailed neuroanatomical distribution map of the cannabinoid type 1 (CB1) receptor, along with the biochemical characterization of the expression and functional coupling to their cognate G i/o ...