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Loss of benefits after cessation of exercise interventions in nursing home residents: randomized controlled trial follow-up
(Elsevier, 2021-05)
Exercise interventions improve physical fitness, cognitive and affective function, and quality of life among nursing home residents. However, little is known regarding the consequences of cessation of activity, or detraining. ...
Conformational Plasticity Underlies Membrane Fusion Induced by an HIV Sequence Juxtaposed to the Lipid Envelope
(Springer Nature, 2021-01-14)
Envelope glycoproteins from genetically-divergent virus families comprise fusion peptides (FPs) that have been posited to insert and perturb the membranes of target cells upon activation of the virus-cell fusion reaction. ...
Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope.
(Nature, 2022)
Antibodies against the carboxy-terminal section of the membrane-proximal external region (C-MPER) of the HIV-1 envelope glycoprotein (Env) are considered as nearly pan-neutralizing. Development of vaccines capable of ...
The Mechanisms of Regulated Cell Death: Structural and Functional Proteomic Pathways Induced or Inhibited by a Specific Protein—A Narrative Review
(MDPI, 2024-01-05)
Billions of cells die in us every hour, and our tissues do not shrink because there is a natural regulation where Cell Death (CD) is balanced with cell division. The process in which cells eliminate themselves in a controlled ...
The Expression of Alamandine Receptor MrgD in Clear Cell Renal Cell Carcinoma Is Associated with a Worse Prognosis and Unfavorable Response to Antiangiogenic Therapy
(MDPI, 2024-01-25)
Renal cell carcinoma (RCC) ranks among the most prevalent malignancies in Western countries, marked by its notable heterogeneity, which contributes to an unpredictable clinical trajectory. The insufficiency of dependable ...
High serum angiotensin-converting enzyme 2 activity as a biomarker of frailty in nursing home residents
(Elsevier, 2022-02)
[EN]Angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) are two of the main components of the renin-angiotensin system (RAS). Imbalanced RAS showing lower ACE2 has been associated with increased ...
Successful breastfeeding among women with intention to breastfeed: From physiology to socio-cultural factors
(Elsevier, 2022-01)
[EN] Background: Even if women have intention to breastfeed, they do not always achieve a successful breastfeeding. Aim: This study aims to analyse factors affecting breastfeeding prevalence among mothers that intended to ...
Despite intention to breastfeed, smoking during pregnancy is associated with shorter breastfeeding duration
(Elsevier, 2023-04)
While maternal smoking is associated with lower breastfeeding rates, the intention to breastfeed is simultaneously related to higher breastfeeding success. This study aimed to i) analyse the association between maternal ...
Reducing Negative Aging Stereotypes via Educational Intervention in Older People: A Randomized Controlled Study
(Sage, 2022-09-13)
Anti-ageism interventions traditionally target younger individuals. We analyzed the effect of an educational intervention that combined an infusion of aging content with videos to reduce negative stereotypes toward aging ...
Therapeutic role of voltage-gated potassium channels in age-related neurodegenerative diseases
(Frontiers Media, 2024-05)
Voltage-gated ion channels are essential for membrane potential maintenance, homeostasis, electrical signal production and controlling the Ca2+ flow through the membrane. Among all ion channels, the key regulators of ...