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Impact of polymorphisms in apoptosis-related genes on the outcome of childhood acute lymphoblastic leukaemia
(Wiley, 2018-05-29)
Despite intensification of therapy, 20% of children with acute lymphoblastic leukaemia (ALL) relapse (Ceppi et al, 2015). The different response to chemotherapy may be partially explained by inherited genetic variants, ...
Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994
(eLife Sciences Publications, 2016-12-14)
Human height variation is determined by genetic and environmental factors, but it
remains unclear whether their influences differ across birth-year cohorts. We conducted an
individual-based pooled analysis of 40 twin ...
A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation
(Nature Publishing Group, 2019-12)
N6-methyladenosine (m6A) is the most common and abundant RNA modification. Recent studies have shown its importance in the regulation of several biological processes, including the immune response, and different approaches ...
The methylome of the celiac intestinal epithelium harbours genotype-independent alterations in the HLA region
(Nature Publishing, 2019-02-04)
The Human Leucocyte Antigen (HLA) locus and other DNA sequence variants identified in Genome-Wide Association (GWA) studies explain around 50% of the heritability of celiac disease (CD). However, the pathogenesis of CD ...
Genetic and environmental influences on height from infancy to early adulthood: An individualbased pooled analysis of 45 twin cohorts
(Nature Research, 2016-06-23)
Height variation is known to be determined by both genetic and environmental factors, but a
systematic description of how their influences differ by sex, age and global regions is lacking. We
conducted an individual-based ...
Association between serum fatty acids and lipoprotein subclass profile in healthy young adults: exploring common genetic and environmental factors
(Elsevier, 2014-01-21)
Objective
Little is known about the associations of serum fatty acids with lipoprotein profile and the underlying genetic and environmental etiology of these relationships. We aimed to analyze the phenotypic association ...
Association of paternal IQ in early adulthood with offspring mortality and hospital admissions for injuries: a cohort study of 503 492 Swedish children
(BMJ Publishing Group, 2014-04-17)
Background Higher intelligence (IQ) has been related to a lower risk of mortality and hospital admissions for injuries, but little is known about the effect of parental IQ on offspring outcomes. We explored associations ...
Genetic and environmental factors affecting birth size variation: a pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts
(Oxford University Press, 2018-05-19)
Background: The genetic architecture of birth size may differ geographically and over
time. We examined differences in the genetic and environmental contributions to birthweight,
length and ponderal index (PI) across ...
Variants in vincristine pharmacodynamic genes involved in neurotoxicity at induction phase in the therapy of pediatric acute lymphoblastic leukemia
(Springer, 2019-02-06)
Vincristine is an important drug of acute lymphoblastic leukemia (ALL) treatment protocols that can cause neurotoxicity. Patients treated with LAL/SHOP protocols often suffer from vincristine-related neurotoxicity in early ...
Lack of association between deficient mismatch repair expression and outcome in endometrial carcinomas of the endometrioid type
(Elsevier, 2014-05-09)
Objective: Endometrial carcinomas of the endometrioid type (EEC) are associated with a good prognosis. However, about 20% of them recur and new prognostic markers are needed. Microsatellite instability (MSI), associated ...