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Association of Current and Former Smoking With Body Mass Index: a Study of Smoking Discordant Twin Pairs From 21 Twin Cohorts
(Public Library Science, 2018-07-12)
Background
Smokers tend to weigh less than never smokers, while successful quitting leads to an increase in body weight. Because smokers and non-smokers may differ in genetic and environmental family background, we ...
Recombinant Integrin β1 Signal Peptide Blocks Gliosis Induced by Aβ Oligomers
(MDPI, 2022-05-20)
Glial cells participate actively in the early cognitive decline in Alzheimer’s disease (AD) pathology. In fact, recent studies have found molecular and functional abnormalities in astrocytes and microglia in both animal ...
The commensal bacterium Lactiplantibacillus plantarum imprints innate memory-like responses in mononuclear phagocytes
(Taylor and Francis, 2021-07-05)
Gut microbiota is a constant source of antigens and stimuli to which the resident immune system has developed tolerance. However, the mechanisms by which mononuclear phagocytes, specifically monocytes/macrophages, cope ...
shinyCurves, a shiny web application to analyse multisource qPCR amplification data: a COVID‑19 case study
(BMC, 2021-10-03)
[EN]Background Quantitative, reverse transcription PCR (qRT-PCR) is currently the gold-standard for SARS-CoV-2 detection and it is also used for detection of other virus. Manual data analysis of a small number of qRT-PCR ...
First computational design using lambda-superstrings and in vivo validation of SARS-CoV-2 vaccine
(Nature Research, 2022-04)
[EN] Coronavirus disease 2019 (COVID-19) is the greatest threat to global health at the present time, and considerable public and private effort is being devoted to fighting this recently emerged disease. Despite the ...
On the Trail of Spatial Patterns of Genetic Variation
(Springer, 2022-03)
[EN] The accurate determination of the spatial trends on the variability of a species' gene pool is essential to elucidate the underlying demographic-evolutionary events, thus helping to unravel the microevolutionary history ...
The Expanded mtDNA Phylogeny of the Franco-Cantabrian Region Upholds the Pre-Neolithic Genetic Substrate of Basques
(Public Library of Science, 2013-07-03)
The European genetic landscape has been shaped by several human migrations occurred since Paleolithic times. The accumulation of archaeological records and the concordance of different lines of genetic evidence during the ...
A Proteomic Approach for Systematic Mapping of Substrates of Human Deubiquitinating Enzymes
(MDPI, 2021-05-03)
The human genome contains nearly 100 deubiquitinating enzymes (DUBs) responsible for removing ubiquitin moieties from a large variety of substrates. Which DUBs are responsible for targeting which substrates remain mostly ...
Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education
(Nature, 2020-05-14)
Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a ...
Does the sex of one’s co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts
(Biomed Central, 2017-04-27)
Background: The comparison of traits in twins from opposite-sex (OS) and same-sex (SS) dizygotic twin pairs is considered a proxy measure of prenatal hormone exposure. To examine possible prenatal hormonal influences on ...