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Variants in vincristine pharmacodynamic genes involved in neurotoxicity at induction phase in the therapy of pediatric acute lymphoblastic leukemia
(Springer, 2019-02-06)
Vincristine is an important drug of acute lymphoblastic leukemia (ALL) treatment protocols that can cause neurotoxicity. Patients treated with LAL/SHOP protocols often suffer from vincristine-related neurotoxicity in early ...
Lack of association between deficient mismatch repair expression and outcome in endometrial carcinomas of the endometrioid type
(Elsevier, 2014-05-09)
Objective: Endometrial carcinomas of the endometrioid type (EEC) are associated with a good prognosis. However, about 20% of them recur and new prognostic markers are needed. Microsatellite instability (MSI), associated ...
Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease
(Elsevier, 2013-12-27)
[EN] Alzheimer's disease (AD) is a neurodegenerative pathology with relevant unmet therapeutic needs. Both natural aging and AD have been associated with a significant decline in the omega-3 polyunsaturated fatty acid ...
Changes in Membrane Organization upon Spontaneous Insertion of 2‑Hydroxylated Unsaturated Fatty Acids in the Lipid Bilayer
(American Chemical Society, 2014-02-03)
Recent research regarding 2-hydroxylated fatty acids (2OHFAs) showed clear evidence of their benefits in the treatment of cancer, inflammation, and neurodegenerative disorders such as Alzheimer’s disease. Monolayer ...
Social Equity Matters in Payments for Ecosystem Services
(Oxford University Press, 2014-09-30)
Although conservation efforts have sometimes succeeded in meeting environmental goals at the expense of equity considerations, the changing context of conservation and a growing body of evidence increasingly suggest that ...
A methodology to determine reliability issues in automotive SiC power modules combining 1D and 3D thermal simulations under driving cycle profiles
(Elsevier, 2019-09-12)
Current environmental concerns and fuel scarcity are leading to the progressive introduction of Electric Vehicles (EV) in the global fleet vehicle population. This requires significant design and research efforts from ...
Structural and magnetic properties of hexagonal Fe3Sn prepared by non-equilibrium techniques
(Elsevier, 2018-07-29)
We report a thorough structural and magnetic study of Fe3Sn produced either by solid state reaction or by mechanical alloying in order to figure out which of the two techniques is most suitable for obtaining the purest ...
Study of the influence of reutilization ionic liquid on lignin extraction
(Elsevier, 2015-04-09)
The development of green techniques for biomass processing and fractionation is crucial from the point of view of sustainability and environmental protection. Lignin is the second most abundant bio-renewable material on ...
Sustainable Alternative of Structural Concrete Retaining Tanks
(Emerald Publishing, 2018-05)
The environmental footprint of the construction industry requires the quantification of new developments to appraise their sustainable contribution. Recent developments in relation to the merging of steel fibre reinforced ...
Study of historical developments in the use of fire resistant steels
(Taylor&Francis, 2014-10-29)
This paper presents a review of the most relevant articles on fire-resistant (FR) steels, as part of a research project at the University of the Basque Country (UPV/EHU) on the FR properties of steelstructures. An important ...