Search
Now showing items 2921-2930 of 2968
Social cognition in myotonic dystrophy type 1: Specific or secondary impairment?
(Public Library Science, 2018-09-24)
Aims
The cognitive profile of Myotonic Dystrophy type 1 (DM1) has been described in recent decades. Moreover, DM1 patients show lowered social engagement and difficulties in social-cognitive functions. The aim of the ...
Genetic Variants in MiRNA Processing Genes and Pre-MiRNAs Are Associated with the Risk of Chronic Lymphocytic Leukemia
(Public Library Science, 2015-03-20)
Genome wide association studies (GWAS) have identified several low-penetrance susceptibility alleles in chronic lymphocytic leukemia (CLL). Nevertheless, these studies scarcely study regions that are implicated in non-coding ...
MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
(Dove Medical Press, 2017-03-27)
Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia ( ALL). Methylenetetrahydrofolate reductase ( MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide ...
Pharmacogenetics of MicroRNAs and MicroRNAs Biogenesis Machinery in Pediatric Acute Lymphoblastic Leukemia
(Public Library Science, 2014-03-10)
Despite the clinical success of acute lymphoblastic leukemia (ALL) therapy, toxicity is frequent. Therefore, it would be useful to identify predictors of adverse effects. In the last years, several studies have investigated ...
A Comprehensive Study of Vesicular and Non-Vesicular miRNAs from a Volume of Cerebrospinal Fluid Compatible with Clinical Practice
(Ivyspring International Publisher, 2019)
Cerebrospinal fluid (CSF) microRNAs (miRNAs) have emerged as potential biomarkers for minimally invasive diagnosis of central nervous system malignancies. However, despite significant advances in recent years, this field ...
Combining random forests and physics-based models to forecast the electricity generated by ocean waves: A case study of the Mutriku wave farm
(Pergamon-Elsevier, 2019-10-01)
This paper combines random forests with physics-based models to forecast the electricity output of the Mutriku wave farm on the Bay of Biscay. The period analysed was 2014-2016, and the forecast horizon was 24 h in 4-h ...
Global estimations of wind energy potential considering seasonal air density changes
(Pergamon-Elsevier, 2019-11-15)
The literature typically considers constant annual average air density when computing the wind energy potential of a given location. In this work, the recent reanalysis ERA5 is used to obtain global seasonal estimates of ...
The return to the Iberian Peninsula: first Quaternary record of Muscardinus and a palaeogeographical overview of the genus in Europe
(Elsevier, 2015-05-18)
Although the earliest record of the genus Muscardinus dates from the Middle Miocene in Spain, no mention has been reported since the Lower Pliocene in the Iberian Peninsula. In this paper, Quaternary fossil remains of a ...
Cohomology of p-groups of nilpotency class smaller than p
(De Gruyter, 2018-01-17)
Let p be a prime number, let d be an integer and let G be a d-generated finite p-group of nilpotency class smaller than p. Then the number of possible isomorphism types for the mod p cohomology algebra H^∗(G;F_p) is bounded ...
Genetic turnovers and northern survival during the last glacial maximum in European brown bears
(John Wiley & Sons, 2019-05-29)
The current phylogeographic pattern of European brown bears (Ursus arctos) has
commonly been explained by postglacial recolonization out of geographically distinct
refugia in southern Europe, a pattern well in accordance ...