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1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death
(Nature Publishing Group, 2013-01)
1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ...
Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead
(MDPI, 2020-03-25)
The retinal ganglion cells (RGCs) are the output cells of the retina into the brain. In mammals, these cells are not able to regenerate their axons after optic nerve injury, leaving the patients with optic neuropathies ...
Sensorized Tip for Monitoring People with Multiple Sclerosis that Require Assistive Devices for Walking
(MDPI, 2020-08-03)
Multiple Sclerosis (MS) is a neurological degenerative disease with high impact on our society. In order to mitigate its effects, proper rehabilitation therapy is mandatory, in which individualisation is a key factor. ...
Monitoring Chest Compression Rate in Automated External Defibrillators Using the Autocorrelation of the Transthoracic Impedance
(Public Library Science, 2020-09-30)
Aim High-quality chest compressions is challenging for bystanders and first responders to out-of-hospital cardiac arrest (OHCA). Long compression pauses and compression rates higher than recommended are common and detrimental ...
Identification of the main allergen sensitizers in an Iran asthmatic population by molecular diagnosis
(Biomed Central, 2014-08-05)
Background: There has been a significant growth in the prevalence of allergy, mainly associated to IgE-mediated disorders such as asthma and rhinitis. The identification of atopy in asthmatic patients through the measurement ...
Digital Quantum Rabi and Dicke Models in Superconducting Circuits
(Nature Publishing Group, 2014-12-15)
We propose the analog-digital quantum simulation of the quantum Rabi and Dicke models using circuit quantum electrodynamics (QED). We find that all physical regimes, in particular those which are impossible to realize in ...
The Forbidden Quantum Adder
(Nature Publishing Group, 2015-07-08)
Quantum information provides fundamentally different computational resources than classical information. We prove that there is no unitary protocol able to add unknown quantum states belonging to different Hilbert spaces. ...
Specific Interaction with Cardiolipin Triggers Functional Activation of Dynamin-Related Protein 1
(Public Library Science, 2014-07-18)
Dynamin-Related Protein 1 (Drp1), a large GTPase of the dynamin superfamily, is required for mitochondrial fission in healthy and apoptotic cells. Drp1 activation is a complex process that involves translocation from the ...
Evaluation of Fentanyl Disposition and Effects in Newborn Piglets as an Experimental Model for Human Neonates
(Public Library Science, 2014-03-04)
Background: Fentanyl is widely used off-label in NICU. Our aim was to investigate its cerebral, cardiovascular and pulmonary effects as well as pharmacokinetics in an experimental model for neonates.
Methods: Fentanyl ...
Biomimetic Cloning of Quantum Observables
(Nature Publishing Group, 2014-05-09)
We propose a bio-inspired sequential quantum protocol for the cloning and preservation of the statistics associated to quantum observables of a given system. It combines the cloning of a set of commuting observables, ...