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Fiber-reinforcement and its effects on the mechanical properties of high-workability concretes manufactured with slag as aggregate and binder
(Elsevier, 2021-11)
[EN]The feasibility of manufacturing fiber-reinforced concretes of high workability through additions of high volumes of electric arc furnace steel slag is evaluated in this paper, using sustainable binders with ground ...
Evolving Gaussian process kernels from elementary mathematical expressions for time series extrapolation
(Elsevier, 2021-10-28)
[EN]Choosing the best kernel is crucial in many Machine Learning applications. Gaussian Processes are a state-of-the-art technique for regression and classification that heavily relies on a kernel function. However, in the ...
Expression and Function of GABA Receptors in Myelinating Cells
(Frontiers Media, 2020-08-21)
Myelin facilitates the fast transmission of nerve impulses and provides metabolic support to axons. Differentiation of oligodendrocyte progenitor cells (OPCs) and Schwann cell (SC) precursors is critical for myelination ...
Ni–Ti-Hf High-Temperature Shape Memory Alloy: Measure of the Clausius-Clapeyron Coefficient Through Mechanical Spectroscopy
(Elsevier, 2021-03-05)
The martensitic transformation of Ni49.5Ti35.5Hf15 high temperature shape memory alloy is characterized by internal friction measurements. The temperatures for the reversible B2 <-> B19' transformation appear in the range ...
BSA- and Elastin-Coated GO, but Not Collagen-Coated GO, Enhance the Biological Performance of Alginate Hydrogels
(MDPI, 2020-06-11)
The use of embedded cells within alginate matrices is a developing technique with great clinical applications in cell-based therapies. However, one feature that needs additional investigation is the improvement of ...
Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia
(Nature Research, 2021-06-25)
The presence of FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) is one of
the most frequent mutations in acute myeloid leukemia (AML) and is associated with an
unfavorable prognosis. FLT3 inhibitors, ...
Approximating the influence coefficients of non-planar elastic solids for conformal contact analysis
(Elsevier, 2021-02)
The exact contact theory is an efficient alternative to the more general yet computationally expensive Finite Element Method for the detailed study of elastostatic contact problems. For its application in conformal contact ...
Overcoming the Inflammatory Stage of Non-Healing Wounds: In Vitro Mechanism of Action of Negatively Charged Microspheres (NCMs)
(MDPI, 2020-06-03)
Negatively charged microspheres (NCMs) represent a new therapeutic approach for wound healing since recent clinical trials have shown NCM efficacy in the recovery of hard-to-heal wounds that tend to stay in the inflammatory ...
Mesenchymal Stromal Cell Secretome for the Treatment of Immune-Mediated Inflammatory Diseases: Latest Trends in Isolation, Content Optimization and Delivery Avenues
(MDPI, 2021-10-27)
Considering the high prevalence and the complex pharmacological management of immune-mediated inflammatory diseases (IMIDs), the search for new therapeutic approaches for their treatment is vital. Although the immunomodulatory ...
Subsynaptic Distribution, Lipid Raft Targeting and G Protein-Dependent Signalling of the Type 1 Cannabinoid Receptor in Synaptosomes from the Mouse Hippocampus and Frontal Cortex
(MDPI, 2021-11-16)
Numerous studies have investigated the roles of the type 1 cannabinoid receptor (CB1) in glutamatergic and GABAergic neurons. Here, we used the cell-type-specific CB1 rescue model in mice to gain insight into the organizational ...