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Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education
(Nature, 2020-05-14)
Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a ...
Analysis on the Characterization of Multiphoton Microscopy Images for Malignant Neoplastic Colon Lesion Detection under Deep Learning Methods
(Wolters Kluwer, 2021-06-21)
Background: Colorectal cancer has a high incidence rate worldwide, with over 1.8 million new cases and 880,792 deaths in 2018. Fortunately, its early detection significantly increases the survival rate, reaching a cure ...
Topical Administration of SLN-Based Gene Therapy for the Treatment of Corneal Inflammation by De Novo IL-10 Production
(MDPI, 2020-06-23)
One of the main challenges in gene therapy is the issue of delivery, and it is especially relevant for the success of gene therapy in the cornea. In the present work, eye drops containing biocompatible non-viral vectors ...
Application of Thermoeconomics in HVAC Systems
(MDPI, 2020-06-17)
In order to achieve a sustainable society, the energy consumption in buildings must be reduced. The first step toward achieving this goal is to detect their weak points and analyze the energy-saving potential. to detect ...
Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis
(MDPI, 2020-06-18)
Background: Alzheimer’s disease (AD) is the most common subtype of dementia. In the last ten years, the relationship between cholesterol and AD has been investigated. Evidence suggests that cholesterol is associated with ...
Microglial Corpse Clearance: Lessons From Macrophages
(Frontiers Media, 2020-03-27)
From development to aging and disease, the brain parenchyma is under the constant threat of debris accumulation, in the form of dead cells and protein aggregates. To prevent garbage buildup, the brain is equipped with ...
Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts
(Nature, 2020-07-29)
We investigated the heritability of educational attainment and how it differed between birth cohorts and cultural-geographic regions. A classical twin design was applied to pooled data from 28 cohorts representing 16 ...
A Clonal NG2-Glia Cell Response in a Mouse Model of Multiple Sclerosis
(MDPI, 2020-05-21)
NG2-glia, also known as oligodendrocyte precursor cells (OPCs), have the potential to generate new mature oligodendrocytes and thus, to contribute to tissue repair in demyelinating diseases like multiple sclerosis (MS). ...
A Series of Vertical Deflections, a Promising Traffic Calming Measure: Analysis and Recommendations for Spacing
(MDPI, 2020-05-13)
Traffic calming measures (TCM) are placed in urban areas to improve road safety, and among them, vertical TCMs are widely employed. Many researches are focused on the influence of the geometry of each measure on speed ...
Nanomedicines to Deliver mRNA: State of the Art and Future Perspectives
(MDPI, 2020-02-20)
The use of messenger RNA (mRNA) in gene therapy is increasing in recent years, due to its unique features compared to plasmid DNA: Transient expression, no need to enter into the nucleus and no risk of insertional mutagenesis. ...