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Now showing items 1671-1680 of 2620
Inhibition of NAE-dependent protein hyper-NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease
(Sage, 2021-09)
Background Polycystic liver diseases (PLDs) are genetic inherited disorders characterized by the progressive growth of numerous intrahepatic biliary cysts, which are the main cause of morbidity. Previous studies revealed ...
Longitudinal Study of Two Virtual Cursors for People With Motor Impairments: A Performance and Satisfaction Analysis on Web Navigation
(IEEE, 2020)
The lack of dexterity in the upper limbs of people with motor impairments may prevent the use of standard pointing devices, such as mice, to access graphical user interfaces. In these cases, pointing and clicking are usually ...
Utrophin modulator drugs as potential therapies for Duchenne and Becker muscular dystrophies
(Wiley, 2021-10)
Utrophin is an autosomal paralogue of dystrophin, a protein whose deficit causes Duchenne and Becker muscular dystrophies (DMD/BMD). Utrophin is naturally overexpressed at the sarcolemma of mature dystrophin-deficient ...
Nutritional Status Is Associated with Function, Physical Performance and Falls in Older Adults Admitted to Geriatric Rehabilitation: A Retrospective Cohort Study
(MDPI, 2020-09-18)
Nutritional status is relevant to functional recovery in patients after an acute process requiring rehabilitation. Nevertheless, little is known about the impact of malnutrition on geriatric rehabilitation. This study aimed ...
Improving Skills in Mechanism and Machine Science Using GIM Software
(MDPI, 2021-08-26)
The field of education has evolved significantly in recent years as it has incorporated new pedagogical methodologies. Many of these methodologies are designed to encourage students’ participation in the learning process. ...
Design and Experimental Characterization of L-CADEL v2, an Assistive Device for Elbow Motion
(MDPI, 2021-07-29)
An experimental characterization is presented for an improved version of a wearable assistive device for elbow motion. The design is revised with respect to requirements for elbow motion assistance, looking at applications ...
Bacterial-Cellulose-Derived Carbonaceous Electrode Materials for Water Desalination Via Capacitive Method: the Crucial Role of Defect Sites
(Elsevier, 2020-10-15)
Electrosorptive desalination is a very simple and appealing approach to satisfy the increasing demand for drinking water. The large-scale application of this technology calls for the development of easy-to-produce, cheap ...
Chiral torsional effects in anomalous fluids in thermal equilibrium
(Scuola Internazionale Superiore di Studi Avanzati (SISSA) ; Springer Verlag, 2021-05-24)
[EN] Using the similarity between spacetime torsion and axial gauge couplings, we
study torsional contributions to the equilibrium partition function in a stationary background.
In the case of a charged fluid minimally ...
Hybrid Optimization Based Mathematical Procedure for Dimensional Synthesis of Slider-Crank Linkage
(MDPI, 2021-07-05)
In this paper, an optimization procedure for path generation synthesis of the slider-crank mechanism will be presented. The proposed approach is based on a hybrid strategy, mixing local and global optimization techniques. ...
Changes in Day/Night Activity in the 6-OHDA-Induced Experimental Model of Parkinson’s Disease: Exploring Prodromal Biomarkers
(Frontiers Media, 2020-10-14)
The search for experimental models mimicking an early stage of Parkinson's disease (PD) before motor manifestations is fundamental in order to explore early signs and get a better prognosis. Interestingly, our previous ...