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Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
(Nature, 2020-07-03)
Nonalcoholic fatty liver disease (NAFLD) is considered the next major health epidemic with an estimated 25% worldwide prevalence. No drugs have yet been approved and NAFLD remains a major unmet need. Here, we identify MCJ ...
Magnesium Accumulation Upon Cyclin M4 Silencing Activates Microsomal Triglyceride Transfer Protein Improving NASH
(Elsevier, 2021-07)
Background & Aims: Perturbations of intracellular magnesium (Mg2+) homeostasis have implications for cell physiology. The cyclin M family, CNNM, perform key functions in the transport of Mg2+ across cell membranes. Herein, ...
Using Common Spatial Patterns to Select Relevant Pixels for Video Activity Recognition
(MDPI, 2020-11-14)
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Using Common Spatial Patterns to Select Relevant Pixels for Video Activity Recognition
by Itsaso Rodríguez-Moreno
* [OrcID] , José María Martínez-Otzeta
[OrcID] , Basilio ...
Targeting UBC9-Mediated Protein Hyper-SUMOylation in Cystic Cholangiocytes Halts Polycystic Liver Disease in Experimental Models
(Elsevier, 2021-02)
BACKGROUND & AIMS: Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of multiple fluid-filled biliary cysts. Most PLD-causative genes participate in protein biogenesis and/or ...
On the Mechanism of Cross-Dehydrogenative Couplings between N-Aryl Glycinates and Indoles: A Computational Study
(American Chemical Society, 2020-09-17)
Despite the widespread use of cross-dehydrogenative couplings in modern organic synthesis, mechanistic studies are still rare in the literature and those applied to α-amino carbonyl compounds remain virtually unexplored. ...
Morphological Analysis of Several Bamboo Species with Potential Structural Applications
(MDPI, 2021-06-28)
Bamboo constitutes a family of plants that are very promising and interesting as renewable materials for both large and small structure construction. To be used as an alternative to traditional materials; the understanding ...
Bearing Assessment Tool for Longitudinal Bridge Performance
(Springer, 2020-11)
This work provides an unsupervised learning approach based on a single-valued performance indicator to monitor the global behavior of critical components in a viaduct, such as bearings. We propose an outlier detection ...
Theoretical Characterization of New Frustrated Lewis Pairs for Responsive Materials
(MDPI, 2021-05-14)
In recent years, responsive materials including dynamic bonds have been widely acclaimed due to their expectation to pilot advanced materials. Within these materials, synthetic polymers have shown to be good candidates. ...
Role of dispersion interactions in Endohedral TM@(ZnS)12 structures
(American Chemical Society, 2021-06-17)
[EN] II−VI semiconducting materials are gaining attention due to
their optoelectronic properties. Moreover, the addition of transition metals,
TMs, might give them magnetic properties. The location and distance of the
TM ...
Pd-Catalyzed C–H Alkoxycarbonylation of Phenethyl- and Benzylamines with Chloroformates as CO Surrogates
(Wiley, 2021-03-26)
The site‐selective functionalization of C−H bonds within a complex molecule remains a challenging task of capital synthetic importance. Herein, an unprecedented Pd‐catalyzed C(sp2)−H alkoxycarbonylation of phenylalanine ...