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Systematic Review of Pharmacogenetic Factors That Influence High-Dose Methotrexate Pharmacokinetics in Pediatric Malignancies
(MDPI, 2021-06-07)
Methotrexate (MTX) is a mainstay therapeutic agent administered at high doses for the treatment of pediatric and adult malignancies, such as acute lymphoblastic leukemia, osteosarcoma, and lymphoma. Despite the vast evidence ...
Problem-Based Learning in University Studies on Renewable Energies: Case of a Laboratory Windpump
(MDPI, 2020-03-23)
In the last eight years, the new faculty of Engineering in Renewable Energies at the University of the Basque Country in Eibar has developed several sustainability goals related to clean energy and climate change, but also ...
The Binding of Aβ42 Peptide Monomers to Sphingomyelin/Cholesterol/Ganglioside Bilayers Assayed by Density Gradient Ultracentrifugation
(MDPI, 2020-02-29)
The binding of Aβ42 peptide monomers to sphingomyelin/cholesterol (1:1 mol ratio) bilayers containing 5 mol% gangliosides (either GM1, or GT1b, or a mixture of brain gangliosides) has been assayed by density gradient ...
Exploring Polar Headgroup Interactions Between Sphingomyelin and Ceramide with Infrared Spectroscopy
(Nature, 2020-10-19)
Ceramide is a major actor in the sphingolipid signaling pathway elicited by various kinds of cell stress. Under those conditions ceramide (Cer) is produced in the plasma membrane as a product of sphingomyelin (SM) hydrolysis, ...
Isothermal oxidation kinetics of nitrided Ti-6Al-4V studied by infrared emissivity
(Elsevier, 2020-08-15)
The oxidation kinetics of Ti-6Al-4V samples nitrided in forming gas (N2+5%H2) between 520 and 805 °C is investigated using infrared emissivity measurements. Several kinetic exponents have been observed depending on temperature ...
Quartzite procurement in conglomerates and deposits:Geoarchaeological characterization of potential catchmentareas in the central part of the Cantabrian Region, Spain
(Wiley, 2021-05)
Raw material characterization in Paleolithic archaeology has widened our knowledge of Middle Paleolithic societies. Procurement of raw material, specifically flint, has allowed the tracing of the mobility of both stones ...
Using Mg/Ca Ratios from the Limpet Patella depressa Pennant, 1777 Measured by Laser-Induced Breakdown Spectroscopy (LIBS) to Reconstruct Paleoclimate
(MDPI, 2021-03-25)
Measurement of the elemental composition of shells is increasingly emerging as an avenue for obtaining high-resolution insights into paleoclimate and past seasonality. Several studies have shown significant correlations ...
SALL1 Modulates CBX4 Stability, Nuclear Bodies, and Regulation of Target Genes
(Frontiers Media, 2021-09-21)
Development is orchestrated through a complex interplay of multiple transcription factors. The comprehension of this interplay will help us to understand developmental processes. Here we analyze the relationship between ...
On pre-emptive vehicle stability control
(Taylor & Francis, 2021-03-30)
[EN] Future vehicle localisation technologies enable major enhancements of vehicle dynamics control. This study proposes a novel vehicle stability control paradigm, based on pre-emptive control that considers the curvature ...
Machine Learning based Fall Detector with a Sensorized Tip
(IEEE, 2021-12-03)
[EN]Fall detection has become an area of interest in recent years, as quick response to these events is critical to reduce the morbidity and mortality rate. In order to ensure proper fall detection, several technologies ...