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Crowding Effects on the Structure and Dynamics of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1
(Frontiers Media, 2021-07-05)
The intracellular environment is crowded with macromolecules, including sugars, proteins and nucleic acids. In the cytoplasm, crowding effects are capable of excluding up to 40% of the volume available to any macromolecule ...
Phase transitions of alkaline-earth metal sulfides under pressure
(IOP Publishing Ltd., 2021-06-21)
[EN] Wehave systematically explored the crystal structures of alkaline-earth metal sulfides under pressure
by using a swarm-intelligence structural prediction method. At low pressures we successfully
reproduced their ...
An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
(Nature, 2020-08-20)
Peptide hormones and neuropeptides encompass a large class of bioactive peptides that regulate physiological processes like anxiety, blood glucose, appetite, inflammation and blood pressure. Here, we execute a focused ...
Reproducibility Study of Nocturnal Blood Pressure Dipping in Patients with High Cardiovascular Risk
(Wiley, 2021-05)
It has been shown that in most people there is a physiological reduction in blood pressure during nighttime sleep, it falling by approximately 10% compared to daytime values (dippers). On the other hand, in some people, ...
Effect of Bacterial Nanocellulose Binding on the Bactericidal Activity of Bovine Lactoferrin
(Elsevier, 2020-07)
Bovine lactoferrin (bLF) has been extensively described as a wide spectrum antimicrobial protein. bLF bactericidal activity has been mainly attributed to two different mechanisms: environmental iron depletion and cell ...
Disruption of Oligodendrocyte Progenitor Cells is an Early Sign of Pathology in the Triple Transgenic Mouse Model of Alzheimer's Disease
(Elsevier, 2020-10)
There is increasing evidence that myelin disruption is related to cognitive decline in Alzheimer's disease (AD). In the CNS, myelin is produced by oligodendrocytes, which are generated throughout life by adult oligodendrocyte ...
The Medication Discrepancy Detection Service: a Cost-Effective Multidisciplinary Clinical Approach
(Doyma, 2021-01)
Objective: To estimate the effectiveness of a Medication Discrepancy Detection Service (MDDS), a collaborative service between the community pharmacy and Primary Care. Design: Non-controlled before-and-after study. Setting: ...
Membrane-Bound sn-1,2-Diacylglycerols Explain the Dissociation of Hepatic Insulin Resistance from Hepatic Steatosis in MTTP Knockout Mice
(American Society for Biochemistry and Molecular Biology, 2020-12)
Microsomal triglyceride transfer protein (MTTP) deficiency results in a syndrome of hypolipidemia and accelerated NAFLD. Animal models of decreased hepatic MTTP activity have revealed an unexplained dissociation between ...
Bayesian Analysis for Cardiovascular Risk Factors in Ischemic Heart Disease
(MDPI, 2021-07-19)
Ischemic heart disease (or Coronary Artery Disease) is the most common cause of death in various countries, characterized by reduced blood supply to the heart. Statistical models make an impact in evaluating the risk factors ...
Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
(MDPI, 2021-06-23)
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, multisystem, and profoundly debilitating condition, probably of multifactorial etiology. No effective approved drugs are currently available for its ...