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Now showing items 11-14 of 14
Detrifluoroacetylative in Situ Generated Cyclic Fluorinated Enolatesfor the Preparation of Compounds Featuring a C−F StereogenicCenter
(American Chemical Society, 2019-11-26)
Practical methods for the preparation of selectively fluorinated compounds are in extremely high demand in nearly every sector of the pharmaceutical and agrochemical industries. Here we provided an account of the recent ...
Development of Hamari Ligands for Practical Asymmetric Synthesisof Tailor-Made Amino Acids
(American Chemical Society, 2019-11-19)
Enantiomerically pure tailor-made amino acids are in extremely high demand in nearly every sector of the health-related industries. In particular, the rapidly growing number of amino-acid-based pharmaceuticals calls for ...
Modeling Antibacterial Activity with Machine Learning and Fusion of Chemical Structure Information with Microorganism Metabolic Networks
(American Chemical Society, 2019-02-25)
Predicting the activity of new chemical compounds over pathogenic microorganisms with different metabolic reaction networks (MRNs) is an important goal due to the different susceptibility to antibiotics. The ChEMBL database ...
Enantioselective Addition of Alkynyl Ketones to Nitroolefins Assisted by Bronsted Base/H-Bonding Catalysis
(Wiley, 2019-03-21)
Various sets of enolizable alkynyl ketones (including methyl ynones with α-aryl, α-alkenyl, and α-alkoxy groups) were able to react smoothly with nitroolefins with the assistance of bifunctional Brønsted base/H-bond catalysts ...