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Pimavanserin exhibits serotonin 5-HT 2A receptor inverse agonism for G αi1 - and neutral antagonism for G αq/11 -proteins in human brain cortex
(Elsevier, 2020-06-07)
[EN] Pimavanserin is claimed as the first antipsychotic drug that shows selectivity for serotonin 5- HT 2 receptors (5-HT 2 Rs) and lacks of affinity for dopamine D 2 receptors (D 2 Rs). Cell-based func- tional assays ...
Environmental enrichment shapes striatal spike-timing-dependent plasticity in vivo
(Nature, 2019-12-19)
Behavioural experience, such as environmental enrichment (EE), induces long-term effects on learning and memory. Learning can be assessed with the Hebbian paradigm, such as spike-timing-dependent plasticity (STDP), which ...
Long-term hippocampal interneuronopathy drives sex-dimorphic spatial memory impairment induced by prenatal THC exposure
(Nature, 2020-04)
Prenatal exposure to Delta(9)-tetrahydrocannabinol (THC), the most prominent active constituent of cannabis, alters neurodevelopmental plasticity with a long-term functional impact on adult offspring. Specifically, THC ...
Serotonin 5-HT2A receptor expression and functionality in postmortem frontal cortex of subjects with schizophrenia: Selective biased agonism via Gαi1-proteins
(Elsevier, 2019-12)
Serotonin 5-HT2A receptors (5-HT(2A)Rs) have been implicated in schizophrenia. However, postmortem studies on 5-HT(2A)Rs expression and functionality in schizophrenia are scarce. The 5-HT2AR mRNA and immunoreactive protein ...
Preclinical Evaluation of an Imidazole-Linked Heterocycle for Alzheimer’s Disease
(MDPI, 2023-09-25)
Humanity is facing a vast prevalence of neurodegenerative diseases, with Alzheimer’s disease (AD) being the most dominant, without efficacious drugs, and with only a few therapeutic targets identified. In this scenario, ...
Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers
(MDPI, 2023-10-25)
Neuroinflammation has a significant impact on different pathologies, such as stroke or spinal cord injury, intervening in their pathophysiology: expansion, progression, and resolution. Neuroinflammation involves oxidative ...
Microarrays, Enzymatic Assays, and MALDI-MS for Determining Specific Alterations to Mitochondrial Electron Transport Chain Activity, ROS Formation, and Lipid Composition in a Monkey Model of Parkinson’s Disease
(MDPI, 2023-03-13)
Multiple evidences suggest that mitochondrial dysfunction is implicated in the pathogenesis of Parkinson’s disease via the selective cell death of dopaminergic neurons, such as that which occurs after prolonged exposure ...
Specific phospholipid modulation by muscarinic signaling in a rat lesion model of Alzheimer's disease
(ACS. American Chemical Society, 2021-05-26)
La enfermedad de Alzheimer (EA) representa la causa más común de demencia en todo el mundo y se ha asociado sistemáticamente con la pérdida de neuronas colinérgicas del cerebro anterior basal (BFCNs) que conducen a una ...
Next-Generation Proteomics of Brain Extracellular Vesicles in Schizophrenia Provide New Clues on the Altered Molecular Connectome
(MDPI, 2024-01-08)
Extracellular vesicles (EVs) are tiny membranous structures that mediate intercellular communication. The role(s) of these vesicles have been widely investigated in the context of neurological diseases; however, their ...
Anatomical location of LPA1 activation and LPA phospholipid precursors in rodent and human brain
(John Wiley & Sons, 2015-04-10)
El ácido lisofosfatídico (LPA) es una molécula de señalización que se une a seis receptores acoplados a proteínas G conocidos: LPA1 -LPA6 . El LPA evoca varias respuestas en el SNC, entre ellas el desarrollo y plegamiento ...