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Lipid fingerprint-based histology accurately classifies nevus, primary melanoma, and metastatic melanoma samples
(Wiley, 2024-02)
Probably, the most important factor for the survival of a melanoma patient is early detection and precise diagnosis. Although in most cases these tasks are readily carried out by pathologists and dermatologists, there are ...
Insights into the mechanism of action of the chlorophyll derivative 13-2-hydroxypheophytine a on reducing neutral lipid reserves in zebrafish larvae and mice adipocytes
(Elsevier, 2023-12)
Obesity is a worldwide epidemic and natural products may hold promise in its treatment. The chlorophyll derivative 13-2-hydroxypheophytine (hpa) was isolated in a screen with zebrafish larvae to identify lipid reducing ...
What motivates students to pursue a career in gerontological nursing? The cultural adaptation and validation of the Spanish version of the CMGN questionnaire
(Elsevier, 2024-04)
Background
Career motivation toward gerontological nursing (CMGN) has been studied by various authors. It is essential to identify the influencing factors and guarantee that undergraduate nursing degrees provide adequate ...
MLe-KCNQ2: An Artificial Intelligence Model for the Prognosis of Missense KCNQ2 Gene Variants
(MDPI, 2024-03-02)
Despite the increasing availability of genomic data and enhanced data analysis procedures, predicting the severity of associated diseases remains elusive in the absence of clinical descriptors. To address this challenge, ...
Do calmodulin binding IQ motifs have built-in capping domains?
(Wiley, 2021-08-15)
Most calmodulin (CaM) targets are alpha-helices. It is not clear if CaM induces the adoption of an alpha-helix configuration to its targets or if those targets are selected as they spontaneously adopt an alpha-helical ...
Fluorometric measurement of calmodulin-dependent peptide–protein interactions using dansylated calmodulin
(Bio-protocol LLC, 2024-04)
The assessment of peptide–protein interactions is a pivotal aspect of studying the functionality and mechanisms of various bioactive peptides. In this context, it is essential to employ methods that meet specific criteria, ...
Sex dependent alteration of epigenetic marks after chronic morphine treatment in mice organs
(Elsevier, 2021-06)
Epigenetic marks may be also affected by several factors, such as age, lifestyle, early life experiences and exposure to chemicals or drugs, such as opioids. Previous studies have focused on how morphine epigenetically ...
Loss of benefits after cessation of exercise interventions in nursing home residents: randomized controlled trial follow-up
(Elsevier, 2021-05)
Exercise interventions improve physical fitness, cognitive and affective function, and quality of life among nursing home residents. However, little is known regarding the consequences of cessation of activity, or detraining. ...
Conformational Plasticity Underlies Membrane Fusion Induced by an HIV Sequence Juxtaposed to the Lipid Envelope
(Springer Nature, 2021-01-14)
Envelope glycoproteins from genetically-divergent virus families comprise fusion peptides (FPs) that have been posited to insert and perturb the membranes of target cells upon activation of the virus-cell fusion reaction. ...
Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope.
(Nature, 2022)
Antibodies against the carboxy-terminal section of the membrane-proximal external region (C-MPER) of the HIV-1 envelope glycoprotein (Env) are considered as nearly pan-neutralizing. Development of vaccines capable of ...