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Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal
(Cell Press, 2018-04-19)
The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, ...
Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal
(Cell Press, 2018-04-19)
Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with ...
Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties
(Nature Publishing, 2019-01-29)
New monosaccharide-based lipid A analogues were rationally designed through MD-2 docking studies. A panel of compounds with two carboxylate groups as phosphates bioisosteres, was synthesized with the same glucosamine-bis-succinyl ...
Automatic Analysis of Archimedes’ Spiral for Characterization of Genetic Essential Tremor Based on Shannon’s Entropy and Fractal Dimension
(MDPI, 2018-07)
Among neural disorders related to movement, essential tremor has the highest prevalence; in fact, it is twenty times more common than Parkinson's disease. The drawing of the Archimedes' spiral is the gold standard test to ...
Discrete Cosine Transform for the Analysis of Essential Tremor
(Frontiers Media, 2019-01-17)
Essential tremor (ET) is the most common movement disorder. In fact, its prevalence is about 20 times higher than that of Parkinson's disease. In addition, studies have shown that a high percentage of cases, between 50 and ...
The Impact of Tumor Eco-Evolution in Renal Cell Carcinoma Sampling
(MDPI, 2018-12-04)
Malignant tumors behave dynamically as cell communities governed by ecological principles. Massive sequencing tools are unveiling the true dimension of the heterogeneity of these communities along their evolution in most ...
Portable and Raman imaging usefulness to detect decaying on mortars from Punta Begoña Galleries (Getxo, North of Spain)
(Wiley, 2016-12)
Punta Begoña Galleries were built in 1918 in Getxo (Basque Country, North of Spain) but were abandoned in 1960. Nowadays, their conservation state is very poor. In this work, portable Raman spectroscopy was applied to ...
Using an Ionic Liquid to Reduce the Electrical Percolation Threshold in Biobased Thermoplastic Polyurethane/Graphene Nanocomposites
(MDPI, 2019-03)
Biobased thermoplastic polyurethane (bTPU)/unmodified graphene (GR) nanocomposites (NCs) were obtained by melt-mixing in a lab-scaled conventional twin-screw extruder. Alternatively, GR was also modified with an ionic ...
Novel Dextran-Supported Biological Probes Decorated with Disaccharide Entities for Investigating the Carbohydrate-Protein Interactions of Gal-3.
(Wiley, 2018-11-30)
The quest for novel natural-like biomolecular probes that can be used to gain information on biological recognition events is of topical interest to several scientific areas. In particular, the recognition of carbohydrates ...
A short in-frame deletion in NTRK1 tyrosine kinase domain caused by a novel splice site mutation in a patient with congenital insensitivity to pain with anhidrosis
(BioMed Central, 2011-06-27)
Background: Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive genetic disease characterized by the lack of reaction to noxious stimuli and anhidrosis. It is caused by mutations in the ...