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Now showing items 1411-1420 of 4794
Fluorinated carbohydrates as chemical probes formolecular recognition studies. Current statusand perspectives
(Royal Society of Chemistry, 2020-06-21)
This review provides an extensive summary of the effects of carbohydrate fluorination with regard to changes in physical, chemical and biological properties with respect to regular saccharides. The specific structural, ...
Unravelling the Time Scale of Conformational Plasticity and Allostery in Glycan Recognition by Human Galectin-1
(Wiley, 2020-12-01)
The interaction of human galectin-1 with a variety of oligosaccharides, from di-(N-acetyllactosamine) to tetra-saccharides (blood B type-II antigen) has been scrutinized by using a combined approach of different NMR ...
Mono and Di-Fucosylated Glycans of the Parasitic Worm S. Mansoniare Recognized Differently by the Innate Immune Receptor DC-SIGN
(Wiley, 2020-12-01)
The parasitic worm,Schistosoma mansoni, expresses unusual fucosylated glycans in a stage-dependent manner that can be recognized by the human innate immune receptor DC-SIGN, thereby shaping host immune responses. We have ...
Investigation of hot char catalytic role in the pyrolysis of waste tires in a two-step process
(Elsevier, 2019-12-30)
[EN] This study pursues the valorization of waste tires by pyrolysis using a different approach for tire parts, specifically, the tire tread rubber and side wall rubber. Tire tread rubber was used to produce hot char with ...
Políticas sobre la integración de las TIC en la escuela de la Comunidad Autónoma del País Vasco
(Universidad de Extremadura, 2011)
[ES]En la Comunidad Autónoma Vasca se han tomado una serie de decisiones estratégicas materializadas en diversas políticas, planes institucionales e iniciativas con el objeto de integrar, usar e innovar con TIC en las ...
USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy
(Biomed Central, 2013)
Reversible protein ubiquitination is emerging as a key process for maintaining cell homeostasis, and the enzymes that participate in this process, in particular E3 ubiquitin ligases and deubiquitinases (DUBs), are increasingly ...
Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage
(Biomed Central, 2015-02-06)
Background: In complex with its cofactor UAF1, the USP1 deubiquitinase plays an important role in cellular processes related to cancer, including the response to DNA damage. The USP1/UAF1 complex is emerging as a novel ...
Two Nuclear Localization Signals in USP1 Mediate Nuclear Import of the USP1/UAF1 Complex
(Public Library of Science, 2012-06-06)
The human deubiquitinase USP1 plays important roles in cancer-related processes, such as the DNA damage response, and the maintenance of the undifferentiated state of osteosarcoma cells. USP1 deubiquitinase activity is ...
In Vitro Surfactant and Perfluorocarbon Aerosol Deposition in a Neonatal Physical Model of the Upper Conducting Airways
(Public Library Science, 2014-09-11)
Objective: Aerosol delivery holds potential to release surfactant or perfluorocarbon (PFC) to the lungs of neonates with respiratory distress syndrome with minimal airway manipulation. Nevertheless, lung deposition in ...
Improved Mechanical Properties of Compatibilized Polypropylene/Polyamide-12 Blends
(Hindawi Publishing Corporation, 2015)
Compatibilized blends of polypropylene (PP) and polyamide-12 (PA12) as a second component were obtained by direct injection molding having first added 20% maleic anhydride-modified copolymer (PP-g-MA) to the PP, which ...