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Now showing items 1421-1430 of 4794
Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness
(Public Library Science, 2015-07-07)
Lymphangioleiomyomatosis (LAM) is a rare lung-metastasizing neoplasm caused by the proliferation of smooth muscle-like cells that commonly carry loss-of-function mutations in either the tuberous sclerosis complex 1 or 2 ...
Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins
(Wiley, 2020-10)
The glycan structures of the receptor binding domain of the SARS-CoV2 spike glycoprotein expressed in human HEK293F cells have been studied by using NMR. The different possible interacting epitopes have been deeply analysed ...
Study of the Phase Transitions in the Binary System NPG-TRIS for Thermal Energy Storage Applications
(MDPI, 2020-03-05)
Neopentylglycol (NPG) and tris(hydroxymethyl)aminomethane (TRIS) are promising phase change materials (PCMs) for thermal energy storage (TES) applications. These molecules undergo reversible solid-solid phase transitions ...
Protein tyrosine phosphatase modulates cell growth and associates with poor outcome in human neuroblastoma
(BMC, 2019-12-14)
Background Protein tyrosine phosphatases (PTPs) regulate neuronal differentiation and survival, but their expression patterns and functions in human neuroblastoma (NB) are scarcely known. Here, we have investigated the ...
Glycan structures and their interactions with proteins. A NMR view
(Elsevier, 2019-12)
Carbohydrate molecules are essential actors in key biological events, being involved as recognition points for cell-cell and cell-matrix interactions related to health and disease. Despite outstanding advances in cryoEM, ...
Structure of a protective epitope reveals the importance of acetylation of Neisseria meningitidis serogroup A capsular polysaccharide
(National Academy of Sciences, 2020-11-24)
Meningococcal meningitis remains a substantial cause of mortality and morbidity worldwide. Until recently, countries in the African meningitis belt were susceptible to devastating outbreaks, largely attributed to serogroup ...
Reprogrammable Permanent Shape Memory Materials Based on Reversibly Crosslinked Epoxy/PCL Blends
(MDPI, 2020-03-29)
Epoxy/Polycaprolactone (PCL) blends cured with a conventional diamine (4,4′-diaminodiphenylmethane, DDM) and with different amounts of a disulfide containing diamine (4, 4´-dithioaniline, DSS) were prepared through melting. ...
Synthetic, Zwitterionic Sp1 Oligosaccharides Adopt a Helical Structure Crucial for Antibody Interaction
(American Chemical Society, 2019-08-28)
The zwitterionic Streptococcus pneumoniae serotype 1 polysaccharide (Sp1) is an important anchor point for our immune system to act against streptococcal infections. Antibodies can recognize Sp1 saccharides, and it has ...
A Methodology to Evaluate the Reliability Impact of the Replacement of Welded Components by Additive Manufacturing Spare Parts
(MDPI, 2019-08-26)
This article shows a method for inspection scheduling of structures made by additive manufacturing, derived from reliability function evaluations and overhaul inspection findings. The routine was an adaption of an existing ...
Las secuencias didácticas de lengua: una encrucijada entre teoría y metodología
(Universidade do Vale do Rio dos Sinos, 2016)
[ES] El objetivo de este trabajo es analizar secuencias didácticas(SD) para enseñar lengua/s diseñadas por profesores de educación primaria y proponer algunos indicadores que guíen a los enseñantes en la confección y ...