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The effect of hydroxylated fatty acid-containing phospholipids in the remodeling of lipid membranes
(Elsevier B.V., 2014-01-24)
The synthetic fatty acid 2-hydroxyoleic acid (2OHOA) is an antitumor drug that regulates membrane lipid composition and structure. An important effect of this drug is the restoration of sphingomyelin (SM) levels in cancer ...
The use of gender-neutral language: Barriers and determinants
(Universidad de Santiago de Chile, 2018)
The main objective of this study is to examine the perceptions about the level of use
of gender-neutral language (GNL) in Spanish. A survey has been designed and used to
analyze the opinions of university teachers in a ...
Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia
(Nature Research, 2017-10-24)
Nucleophosmin (NPM) is a nucleolar protein involved in ribosome assembly and cell homeostasis. Mutations in the C-terminal domain of NPM that impair native folding and localization are associated with acute myeloid leukemia ...
Sobre las precipitaciones de octubre de 2012 en el Pirineo Aragonés, su respuesta hidrológica y la gestión de riesgos
(Universidad de Zaragoza, 2012)
[ES]Intensas precipitaciones en los días 19 y 20 de octubre de2012 generaron crecidas en toda la red fluvial de los afluentes pirenaicos de la cuenca del Ebro. Se presentan brevemente los registros de precipitación alcanzados, ...
Partitioning of liquid-ordered/liquid-disordered membrane microdomains induced by the fluidifying effect of 2-hydroxylated fatty acid derivatives
(2013-06-18)
[EN] Cellular functions are usually associated with the activity of proteins and nucleic acids. Recent studies have shown that lipids modulate the localization and activity of key membrane-associated signal transduction ...
Shortcuts to adiabaticity in optical waveguides using fast quasiadiabatic dynamics
(Optica Publishing Group, 2017-01-03)
We propose a fast quasiadiabatic approach to the design of optical waveguide devices. This approach distributes the system adiabaticity homogeneously over the device length, thus providing a shortcut to adiabaticity at a ...
Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge
(Nature Publishing, 2017-11-15)
Specific protein-lipid interactions lead to a gradual recruitment of AuTophaGy-related (ATG) proteins to the nascent membrane during autophagosome (AP) formation. ATG3, a key protein in the movement of LC3 towards the ...
Triacylglycerol mimetics regulate membrane interactions of glycogen branching enzyme: implications for therapy
(Elsevier, 2017-06-19)
Adult polyglucosan body disease (APBD) is a neurological disorder characterized by adult-onset neurogenic bladder, spasticity, weakness, and sensory loss. The disease is caused by aberrant glycogen branching enzyme (GBE) ...
Solvent and catalyst effect in the formic acid aided lignin-to-liquids
(Elsevier, 2018-09-13)
[EN] The effect of the type of solvent, ethanol or water, and a Ru/C catalyst were studied in the formic acid aided lignin conversion. The best results were obtained in the presence of the Ru/C catalyst and using ethanol ...
Pb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells
(Nature Publishing, 2018-05-10)
The mechanisms of Pb(II) toxicity have been studied in human red blood cells using confocal microscopy, immunolabeling, fluorescence-activated cell sorting and atomic force microscopy. The process follows a sequence of ...