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A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis
(Oxford University Pres, 2015-10-01)
Several variants in strong linkage disequilibrium (LD) at the SP140 locus have been associated with multiple sclerosis (MS), Crohn's disease (CD) and chronic lymphocytic leukemia (CLL). To determine the causal polymorphism, ...
A New Approach For Determining The R-Curve In DCB Tests Without Optical Measurements
(Elsevier, 2015-02)
A new method for obtaining the R-curve point to point by the Double Cantilever Beam test is proposed. Besides the determination of new compliance and energy release rate equations, the analytical model presented leads to ...
Experiments of Trust Prediction in Social Networks by Artificial Neural Networks
(Taylor and Francis, 2015-03-24)
Social network online services are growing at an exponential pace, both in quantity of users and diversity of services; thus, the evaluation of trust in the interaction among users and toward the system is a central issue ...
Influence of the regulation framework on the feasibility of a Stirling engine-based residential micro-CHP installation
(Elsevier, 2015-04-07)
In this paper an economic analysis of a 1 kWe Stirling engine-based micro-CHP (combined heat and power) residential plant is developed, approaching the case of a Spanish detached house sited in a cold climatic zone. The ...
Relevance for decision making of spatially explicit, participatory scenarios for ecosystem services in an area of a high current demand
(Elsevier, 2015-07-23)
Participatory ecosystem services scenarios can be used to inform decision making on the sustainable or wise use of biodiversity and Ecosystem Services (ES). To establish the plausibility and coherency of the recently ...
Provisioning ecosystem services supply and demand: the role of landscape management to reinforce supply and promote synergies with other ecosystem services
(Elsevier, 2015-03-14)
Currently, trade enables regions to have a higher provisioning ecosystem services (ES) demand than that provided by ecosystems in the same region. This practice leads to a supply and demand provisioning ES scale mismatch, ...
Activity-associated effect of LDL receptor missense variants located in the cysteine-rich repeats
(Elsevier, 2015-02)
Background: The LDL receptor (LDLR) is a Class I transmembrane protein critical for the clearance of cholesterol-containing lipoprotein particles. The N-terminal domain of the LDLR harbours the ligand-binding domain ...
Analysis of a reversible five-point bending configuration based on a novel two-sense support
(Elsevier, 2015-05)
A novel two-sense support for flexural tests has been designed and manufactured in Ikerlan. The aim of this support is to do two-sense bending fatigue tests. In order to reduce the displacement corresponding to a given ...
Anatomical location of LPA1 activation and LPA phospholipid precursors in rodent and human brain
(John Wiley & Sons, 2015-04-10)
El ácido lisofosfatídico (LPA) es una molécula de señalización que se une a seis receptores acoplados a proteínas G conocidos: LPA1 -LPA6 . El LPA evoca varias respuestas en el SNC, entre ellas el desarrollo y plegamiento ...
An efficient implementation of kernel density estimation for multi-core and many-core architectures
(Sage, 2015-03-16)
Kernel density estimation (KDE) is a statistical technique used to estimate the probability density function of a sample set with unknown density function. It is considered a fundamental data-smoothing problem for use with ...