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Now showing items 141-149 of 149
Gene delivery in the cornea: in vitro and ex vivo evaluation of solid lipid nanoparticle-based vectors
(Future Medicine, 2018-08-01)
Inflammation is a process that underlies sight-threatening ocular surface
diseases, and gene supplementation with the plasmid that encodes for interleukin-10 (p-
IL10) will allow the sustained de novo synthesis of the ...
Improvement of the monitoring and biosafety of encapsulated cells using the SFGNESTGL triple reporter system
(Elsevier, 2010-05-23)
Cell microencapsulation may represent a breakthrough to overcome problems associated with cell therapy. Advances in material biocompatibility and production protocols have put this field close to its clinical application. ...
Inactivation of encapsulated cells and their therapeutic effects by means of TGL triple-fusion reporter/biosafety gene
(Elsevier, 2012-11-19)
The immobilization of cells within alginate-poly-l-lysine-alginate (APA) microcapsules has been demonstrated to be an effective technology design for long term delivery of therapeutic products. Despite promising advances, ...
Novel Population Pharmacokinetic Model for Linezolid in Critically Ill Patients and Evaluation of the Adequacy of the Current Dosing Recommendation
(MDPI, 2020-01-09)
Antimicrobial treatment in critically ill patients remains challenging. The aim of this study
was to develop a population pharmacokinetic model for linezolid in critically ill patients and to
evaluate the adequacy of ...
Novel advances in the design of three-dimensional bio-scaffolds to control cell fate: translation from 2D to 3D
(Elsevier, 2012-05-07)
Recreating the most critical aspects of the native extracellular matrix (ECM) is fundamental to understand and control the processes regulating cell fate and cell function. From the ill-defined complexity to the controlled ...
Has the adipokine profile an influence on the catch-up growth type in small for gestational age infants?
(Springer, 2019-06-17)
[EN] Infants born small for gestational age (SGA) are at increased risk of perinatal morbidity, persistent short stature, and metabolic alterations in later life. Moreover, the post-natal growth pattern of SGA infants may ...
Optimization of 100 µm alginate-poly-L-lysine-alginate capsules for intravitreous administration
(Elsevier, 2011-09-24)
The field of cell microencapsulation is advancing rapidly. Particle size plays a critical role in terms of biocompatibility and limits decisively its applicability. Producing reduced size microcapsules involves broadening ...
Omega‐3 LCPUFA supplement: a nutritional strategy to prevent maternal and neonatal oxidative stress
(Wiley, 2016-04-13)
There is controversy about fish‐oil supplementation and oxidative damage. This ambiguity should be explored to elucidate its role as modulator of oxidative stress, especially during gestation and postnatal life. This is ...
The synergistic effects of the RGD density and the microenvironment on the behavior of encapsulated cells: In vitro and in vivo direct comparative study
(John Wiley & Sons, 2014-11)
The inclusion of the tripeptide RGD (Arg-Gly-Asp) in otherwise inert biomaterials employed for cell encapsulation has been observed to be an effective strategy to provide the immobilized cells with a more suitable ...