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Now showing items 9951-9960 of 10380
LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs
(Taylor & Francis, 2022-12)
Externalization of the phospholipid cardiolipin (CL) to the outer mitochondrial membrane has been proposed to act as a mitophagy trigger. CL would act as a signal for binding the LC3 macroauto-phagy/autophagy proteins. As ...
Experimental method for estimating the effect of solar radiation on the inner surface heat flux of opaque building envelope elements
(SAGE, 2024-04-10)
There still exists a considerable difference when comparing the real and the design energy consumption of buildings. The difference between the design and the real building envelope energy performance is one of its main ...
Iconic Architecture as a Catalyst for Wine Tourism: A Case Study of Marqués de Riscal.
(Sciendo (De Gruyter), 2024-04-02)
This article explores the intersection between Frank Gehry's iconic Hotel Marqués de Riscal (MdR) and the Marques de Riscal winery, investigating their causal relationship with the surge in wine tourism. Using Google Trends ...
Effect of ATG12–ATG5-ATG16L1 autophagy E3-like complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion
(Springer, 2023-02)
In macroautophagy, the autophagosome (AP) engulfs portions of cytoplasm to allow their lysosomal degradation. AP formation in humans requires the concerted action of the ATG12 and LC3/GABARAP conjugation systems. The ...
Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia
(Nature Research, 2017-10-24)
Nucleophosmin (NPM) is a nucleolar protein involved in ribosome assembly and cell homeostasis. Mutations in the C-terminal domain of NPM that impair native folding and localization are associated with acute myeloid leukemia ...
Sobre las precipitaciones de octubre de 2012 en el Pirineo Aragonés, su respuesta hidrológica y la gestión de riesgos
(Universidad de Zaragoza, 2012)
[ES]Intensas precipitaciones en los días 19 y 20 de octubre de2012 generaron crecidas en toda la red fluvial de los afluentes pirenaicos de la cuenca del Ebro. Se presentan brevemente los registros de precipitación alcanzados, ...
Partitioning of liquid-ordered/liquid-disordered membrane microdomains induced by the fluidifying effect of 2-hydroxylated fatty acid derivatives
(2013-06-18)
[EN] Cellular functions are usually associated with the activity of proteins and nucleic acids. Recent studies have shown that lipids modulate the localization and activity of key membrane-associated signal transduction ...
Shortcuts to adiabaticity in optical waveguides using fast quasiadiabatic dynamics
(Optica Publishing Group, 2017-01-03)
We propose a fast quasiadiabatic approach to the design of optical waveguide devices. This approach distributes the system adiabaticity homogeneously over the device length, thus providing a shortcut to adiabaticity at a ...
Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge
(Nature Publishing, 2017-11-15)
Specific protein-lipid interactions lead to a gradual recruitment of AuTophaGy-related (ATG) proteins to the nascent membrane during autophagosome (AP) formation. ATG3, a key protein in the movement of LC3 towards the ...
Triacylglycerol mimetics regulate membrane interactions of glycogen branching enzyme: implications for therapy
(Elsevier, 2017-06-19)
Adult polyglucosan body disease (APBD) is a neurological disorder characterized by adult-onset neurogenic bladder, spasticity, weakness, and sensory loss. The disease is caused by aberrant glycogen branching enzyme (GBE) ...