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Genetic Variants Associated with Colorectal Adenoma Susceptibility
(PUBLIC LIBRARY SCIENCE, 2016-04-14)
Background
Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk.
Aim
To determine if these genetic variants are associated also with adenoma susceptibility and may ...
The MLH1 c.1852_1853delinsGC (p.K618A) Variant in Colorectal Cancer: Genetic Association Study in 18,723 Individuals
(Public Library Science, 2014-04-17)
Colorectal cancer is one of the most frequent neoplasms and an important cause of mortality in the developed world. Mendelian syndromes account for about 5% of the total burden of CRC, being Lynch syndrome and familial ...
Integrated Analysis of Germline and Tumor DNA Identifies New Candidate Genes Involved in Familial Colorectal Cancer
(MDPI, 2019-03-13)
Colorectal cancer (CRC) shows aggregation in some families but no alterations in the known hereditary CRC genes. We aimed to identify new candidate genes which are potentially involved in germline predisposition to familial ...