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Mass spectrometry coupled to imaging techniques: The better the view the greater the challenge
(Frontiers Research Foundation, 2015-01-21)
These are definitively exciting times for membrane lipid researchers. Once considered just as the cell membrane building blocks, the important role these lipids play is steadily being acknowledged. The improvement occurred ...
Domain Organization, Catalysis and Regulation of Eukaryotic Cystathionine Beta-Synthases
(Public Library Science, 2014-08-14)
Cystathionine beta-synthase (CBS) is a key regulator of sulfur amino acid metabolism diverting homocysteine, a toxic intermediate of the methionine cycle, via the transsulfuration pathway to the biosynthesis of cysteine. ...
Anatomical distribution of lipids in human brain cortex by imaging mass spectrometry
(Springer Verlag, 2011-01-28)
[ES] Las imágenes de masa molecular de los tejidos estarán sesgadas si las diferencias en las propiedades fisicoquímicas del microentorno afectan a la intensidad de los espectros. Para abordar esta cuestión, hemos realizado ...
Competition between stacked and hydrogen bonded structures of cytosine aggregates
(RSC, 2017)
The four bases of DNA constitute what is known as the “alphabet of life”. Their combination of proton-donor and acceptor groups and aromatic rings allows them to form stacking structures and at the same time establish ...
Exploring Caffeine–Phenol Interactions by the Inseparable Duet of Experimental and Theoretical Data
(Wiley, 2019-11)
Intermolecular interactions are difficult to model, especially in systems formed by multiple interactions. Such is the case of caffeine–phenol. Structural data has been extracted by using mass-resolved excitation spectroscopy ...
High conductance values in pi-folded molecular junctions
(Nature Publishing, 2017-05-18)
Folding processes play a crucial role in the development of function in biomacromolecules. Recreating this feature on synthetic systems would not only allow understanding and reproducing biological functions but also ...
Modeling the tyrosine–sugar interactions in supersonic expansions: glucopyranose–phenol clusters
(RSC, 2016-03-14)
Sugars are fundamental building blocks for living organisms and their interaction with proteins plays a central
role in fundamental biological processes, such as energy storage and production, post-transductional
modifications ...
The Six Isomers of the Cyclohexanol Dimer: A Delicate Test for Dispersion Models
(Wiley, 2020)
The cyclohexanol homodimer acts as a delicate test model of the role of dispersion forces in intermolecular association. Whereas phenol produces a single dimer, the suppression of π interactions and the larger conformational ...
Sugar–peptidic bond interactions: spectroscopic characterization of a model system
(2017-04-11)
Sugars are small carbohydrates which perform numerous roles in living
organisms such as storage of energy or as structural components. Modifications of specific sites
within the glycan chain can modulate a carbohydrate’s ...