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D5 dopamine receptors control glutamatergic AMPA transmission between the motor cortex and subthalamic nucleus
(Nature Publishing, 2018-06-11)
Corticofugal fibers target the subthalamic nucleus (STN), a component nucleus of the basal ganglia, in addition to the striatum, their main input. The cortico-subthalamic, or hyperdirect, pathway, is thought to supplement ...
Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants
(Biomed Central, 2018-09-04)
Background: Studies show that Toll-like receptors (TLRs), members of the innate immune system, might participate in the pathogenesis of the major depressive disorder (MDD). However, evidence of this participation in the ...
Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping Out of the Striatum
(MDPI, 2019-08-29)
The basal ganglia (BG) are a collection of interconnected subcortical nuclei that participate in a great variety of functions, ranging from motor programming and execution to procedural learning, cognition, and emotions. ...
Pivoting between Calmodulin Lobes Triggered by Calcium in the Kv7.2/Calmodulin Complex
(Public Library Science, 2014-01-28)
Kv7.2 (KCNQ2) is the principal molecular component of the slow voltage gated M-channel, which strongly influences neuronal excitability. Calmodulin (CaM) binds to two intracellular C-terminal segments of Kv7.2 channels, ...
Cytokine pathway disruption in a mouse model of schizophrenia induced by Munc18-1a overexpression in the brain
(Biomed Central, 2014-07-29)
Background: An accumulating body of evidence points to the significance of neuroinflammation and immunogenetics in schizophrenia, and an imbalance of cytokines in the central nervous system (CNS) has been suggested to be ...
Decreased Striatal Adenosine A(2A)-Dopamine D(2)Receptor Heteromerization in Schizophrenia
(Springer Nature, 2020-10-03)
According to the adenosine hypothesis of schizophrenia, the classically associated hyperdopaminergic state may be secondary to a loss of function of the adenosinergic system. Such a hypoadenosinergic state might either be ...
Calcium-binding proteins are altered in the cerebellum in schizophrenia
(Public Library Science, 2020-07-08)
Alterations in the cortico-cerebellar-thalamic-cortical circuit might underlie the diversity of symptoms in schizophrenia. However, molecular changes in cerebellar neuronal circuits, part of this network, have not yet been ...
Editorial: Non-Dopaminergic Systems in Parkinson's Disease
(Frontiers Media, 2020-09-11)
The dopaminergic system has been the main focus for almost 70 years and dopaminergic-based strategies still remain the best symptomatic medication to improve quality of life of parkinsonian patients.
Dopaminergic control of ADAMTS2 expression through cAMP/CREB and ERK: molecular effects of antipsychotics
(Nature, 2019-11-18)
A better understanding of the molecular mechanisms that participate in the development and clinical manifestations of schizophrenia can lead to improve our ability to diagnose and treat this disease. Previous data strongly ...
Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results
(Dove Medical Press, 2014)
Based on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and behavioral levels, a new series of hybrid molecules has been prepared ...