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Prediction of Multi-Target Networks of Neuroprotective Compounds with Entropy Indices and Synthesis, Assay, and Theoretical Study of New Asymmetric 1,2-Rasagiline Carbamates
(MDPI, 2014-09)
In a multi-target complex network, the links (L-ij) represent the interactions between the drug (d(i)) and the target (t(j)), characterized by different experimental measures (K-i, K-m, IC50, etc.) obtained in pharmacological ...
Favoring Trienamine Activation through Unconjugated Dienals: Organocatalytic Enantioselective Remote Functionalization of Alkenes
(Wiley-VCH, 2014-01-29)
Unconjugated 2,5-dienals are more reactive substrates
than the corresponding fully conjugated a,b,g,dunsaturated
aldehydes towards organocatalytic activation
through trienamine intermediates. This difference in ...