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Metabolic efficiency with fast spiking in the squid axon
(Frontiers, 2012-11-15)
Fundamentally, action potentials in the squid axon are consequence of the entrance of sodium ions during the depolarization of the rising phase of the spike mediated by the outflow of potassium ions during the hyperpolarization ...
The Cryo-EM Structure of a Complete 30S Translation Initiation Complex from Escherichia coli
(Public Library of Science, 2011-07-05)
Formation of the 30S initiation complex (30S IC) is an important checkpoint in regulation of gene expression. The selection of mRNA, correct start codon, and the initiator fMet-tRNA(fMet) requires the presence of three ...
Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease
(Portland Press, 2011)
The EC (entorhinal cortex) is fundamental for cognitive and mnesic functions. Thus damage to this area appears as a key element in the progression of AD (Alzheimer's disease), resulting in memory deficits arising from ...
Spinal circuits can accommodate interaction torques during multijoint limb movements
(Frontiers Research Foundation, 2014-11-11)
The dynamic interaction of limb segments during movements that involve multiple joints creates torques in one joint due to motion about another. Evidence shows that such interaction torques are taken into account during ...
Effects of Spring Temperatures on the Strength of Selection on Timing of Reproduction in a Long-Distance Migratory Bird
(Public Library Science, 2015-04)
Climate change has differentially affected the timing of seasonal events for interacting trophic levels, and this has often led to increased selection on seasonal timing. Yet, the environmental variables driving this ...
Physiological modules for generating discrete and rhythmic movements: action identification by a dynamic recurrent neural network
(Frontiers Research Foundation, 2014-09-17)
In this study we employed a dynamic recurrent neural network (DRNN) in a novel fashion to reveal characteristics of control modules underlying the generation of muscle activations when drawing figures with the outstretched ...
Physiological modules for generating discrete and rhythmic movements: Component analysis of EMG signals
(Frontiers Research Foundation, 2015-01-09)
A central question in Neuroscience is that of how the nervous system generates the spatiotemporal commands needed to realize complex gestures, such as handwriting. A key postulate is that the central nervous system (CNS) ...
From the Cajal alumni Achucarro and Rio-Hortega to the rediscovery of never-resting microglia
(Frontiers Research Foundation, 2015-04-14)
Under the guidance of Ramon y Cajal, a plethora of students flourished and began to apply his silver impregnation methods to study brain cells other than neurons: the neuroglia. In the first decades of the twentieth century, ...
Energy demands of diverse spiking cells from the neocortex, hippocampus, and thalamus
(Frontiers Research Foundation, 2014-04-08)
It has long been known that neurons in the brain are not physiologically homogeneous. In response to current stimulus, they can fire several distinct patterns of action potentials that are associated with different ...
Classification of neocortical interneurons using affinity propagation
(Frontiers Reseach Foundation, 2013-12)
In spite of over a century of research on cortical circuits, it is still unknown how many classes of cortical neurons exist. Neuronal classification has been a difficult problem because it is unclear what a neuronal cell ...