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Augmented Renal Clearance in Critically Ill Patients: A Systematic Review
(Springer, 2018-02-13)
Background Traditionally, renal function in critically ill patients has been assessed to identify renal dysfunction, and dose adjustment is generally accepted in such a context.
Nevertheless, augmented renal clearance ...
Pharmacokinetic/pharmacodynamic analysis as a tool for surveillance of the activity of antimicrobials against Pseudomonas aeruginosa strains isolated in critically ill patients
(Elsevier, 2018-10-11)
Introduction: To evaluate the changes in the susceptibility of Pseudomonas aeruginosa overtime (2000–2017) against antimicrobials used in an intensive care unit of a Spanish tertiaryhospital, and to compare them with the ...
Population pharmacokinetics of daptomycin in critically ill patients
(Elsevier, 2018-03-20)
Daptomycin has shown activity against a wide range of Gram-positive bacteria; however, the approved dosages usually seem insufficient for critically ill patients. The aim of this study was to develop a population pharmacokinetic ...
Gene delivery in the cornea: in vitro and ex vivo evaluation of solid lipid nanoparticle-based vectors
(Future Medicine, 2018-08-01)
Inflammation is a process that underlies sight-threatening ocular surface
diseases, and gene supplementation with the plasmid that encodes for interleukin-10 (p-
IL10) will allow the sustained de novo synthesis of the ...