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Heart-brain synchronization breakdown in Parkinson's disease
(Nature, 2022-05)
Heart rate variability (HRV) abnormalities are potential early biomarkers in Parkinson's disease (PD) but their relationship with central autonomic network (CAN) activity is not fully understood. We analyzed the synchronization ...
Potential Tear Biomarkers for the Diagnosis of Parkinson’s Disease—A Pilot Study
(MDPI, 2022-01-13)
Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. In this study, the tear proteome profile of patients with idiopathic PD (iPD, n = 24), carriers of the E46K-SNCA ...
Brain fog of post-COVID-19 condition and Chronic Fatigue Syndrome, same medical disorder?
(BMC, 2022-12)
Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is characterized by persistent physical and mental fatigue. The post-COVID-19 condition patients refer physical fatigue and cognitive impairment ...
Spatial characterization of the effect of age and sex on macular layer thicknesses and foveal pit morphology
(Public Library Science, 2022-12)
Characterizing the effect of age and sex on macular retinal layer thicknesses and foveal pit morphology is crucial to differentiating between natural and disease-related changes. We applied advanced image analysis techniques ...
Diagnostic classification of Parkinson’s disease based on non-motor manifestations and machine learning strategies
(Springer, 2023-03)
Non-motor manifestations of Parkinson’s disease (PD) appear early and have a significant impact on the quality of life of patients, but few studies have evaluated their predictive potential with machine learning algorithms. ...
Quantitative analysis of dysautonomia in patients with autonomic dysreflexia
(Springer, 2021-02-25)
Autonomic dysreflexia (AD) is a life-threatening condition for individuals with cervical or high-thoracic spinal cord injury (SCI). The profile of autonomic dysfunction in AD using validated clinical autonomic tests has ...
Myocardial MIBG scintigraphy in genetic Parkinson’s disease as a model for Lewy body disorders
(Springer-Verlag, 2018-10-15)
Purpose To identify myocardial sympathetic denervation patterns suggestive of Lewy body (LB) pathology in patients with genetic and idiopathic parkinsonisms by 123I-metaiodobenzylguanidine (MIBG) scintigraphy. Methods We ...
Small fiber neuropathy and phosphorylated alpha-synuclein in the skin of E46K- SNCA mutation carriers
(Elsevier, 2019-06-05)
Background and objective: In 2004 we described the E46K mutation in alpha-synuclein gene (E46K-SNCA), a rare point mutation causing an aggressive Lewy body disease with early prominent non-motor features and small fiber ...
Autonomic dysfunction is associated with neuropsychological and neuropsychiatric impairment in patients with Lewy body diseases
(Springer-Verlag GmbH Germany, 2020-03-13)
Objective: This study aimed to analyze the association of autonomic dysfunction with cognition, depression, apathy, and fatigue in Lewy body disease (LBD).
Methods: We included 61 patients [49 with idiopathic Parkinson’s ...
Prognostic factors for falls in Parkinson’s disease: a systematic review
(Springer Nature, 2024)
Background Falls represent a critical concern in Parkinson’s disease (PD), contributing to increased morbidity and reduced
quality of life.
Purpose We conducted a systematic review to assess the prognostic factors ...