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Cell-Centric View of Apoptosis and Apoptotic Cell Death-Inducing Antitumoral Strategies
(MDPI, 2011-03-03)
Programmed cell death and especially apoptotic cell death, occurs under physiological conditions and is also desirable under pathological circumstances. However, the more we learn about cellular signaling cascades, the ...
A Customized Pigmentation SNP Array Identifies a Novel SNP Associated with Melanoma Predisposition in the SLC45A2 Gene
(Public Library of Science, 2011-04-29)
As the incidence of Malignant Melanoma (MM) reflects an interaction between skin colour and UV exposure, variations in genes implicated in pigmentation and tanning response to UV may be associated with susceptibility to ...
Involvement of ANXA5 and ILKAP in Susceptibility to Malignant Melanoma
(Public Library Science, 2014-04-17)
Single nucleotide-polymorphisms (SNPs) are a source of diversity among human population, which may be responsible for the different individual susceptibility to diseases and/or response to drugs, among other phenotypic ...
BRAF V600E mutational load as a prognosis biomarker in malignant melanoma
(Public Library Science, 2020-03-13)
Analyzing the mutational load of driver mutations in melanoma could provide valuable information regarding its progression. We aimed at analyzing the heterogeneity of mutational load of BRAF V600E in biopsies of melanoma ...
RKIP Regulates Differentiation-Related Features in Melanocytic Cells
(MDPI, 2020-06-03)
Raf Kinase Inhibitor Protein (RKIP) has been extensively reported as an inhibitor of keysignaling pathways involved in the aggressive tumor phenotype and shows decreased expressionin several types of cancers. However, ...
Serum markers improve current prediction of metastasis development in early-stage melanoma patients: a machine learning-based study
(Wiley, 2020-06)
Metastasis development represents an important threat for melanoma patients, even when diagnosed at early stages and upon removal of the primary tumor. In this scenario, determination of prognostic biomarkers would be of ...
Innate Lymphoid Cells in the Malignant Melanoma Microenvironment
(MDPI, 2020-10-29)
The role of innate lymphoid cells (ILCs) in cancer progression has been uncovered in recent years. ILCs are classified as Type 1, Type 2, and Type 3 ILCs, which are characterized by the transcription factors necessary for ...
Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells
(BioMed Central, 2011-10-07)
Background -- N-(4-hydroxyphenyl)retinamide (4-HPR, fenretinide) is a synthetic retinoid with potent pro-apoptotic activity against several types of cancer, but little is known regarding mechanisms leading to chemoresistance. ...