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Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response

Gómez Fernández, Paloma; Urtasun Arricaberri, Andoni; Paton, Adrienne W.; Paton, James C.; Borrego, Francisco; Dersh, Devin; Argon, Yair; Alloza Moral, Iraide; Vandenbroeck, Koen (Frontiers Media, 2018-12-14)

The human IL22RA2 gene co-produces three protein isoforms in dendritic cells [IL-22 binding protein isoform-1 (IL-22BPi1), IL-22BPi2, and IL-22BPi3]. Two of these, IL-22BPi2 and IL-22BPi3, are capable of neutralizing the ...

Characterization of Carotid Smooth Muscle Cells during Phenotypic Transition

Goikuria Iriondo, Haize; Freijo, María del Mar; Vega Manrique, Reyes; Sastre, María; Elizagaray, Elena; Lorenzo, Ana; Vandenbroeck, Koen; Alloza Moral, Iraide (MDPI, 2018-03)

Vascular smooth muscle cells (VSMCs) are central players in carotid atherosclerosis plaque development. Although the precise mechanisms involved in plaque destabilization are not completely understood, it is known that ...