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Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport

Arregi Vado, Igor; Falces, Jorge; Olazabal Herrero, Ane; Alonso Mariño, Marian; Taneva, Stefka G.; Rodríguez Pérez, José Antonio; Urbaneja Arrue, María Ángeles; Bañuelos Rodríguez, Sonia (Public Library of Science, 2015-06-19)

Nucleophosmin (NPM) is a nucleocytoplasmic shuttling protein, normally enriched in nucleoli, that performs several activities related to cell growth. NPM mutations are characteristic of a subtype of acute myeloid leukemia ...