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Resveratrol inhibits nonalcoholic fatty liver disease in rats
(BioMed Central, 2008-09-09)
Background: The prevalence of nonalcoholic fatty liver disease (NAFLD) is high. NAFLD is linked to obesity, diabetes mellitus, and hypertriglyceridemia. Approximately 20% of patients with NAFLD will eventually develop ...
Inflammatory Mediators of Hepatic Steatosis
(Hindawi Publishing Corporation, 2010)
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming a world-wide public health problem. NAFLD represents a spectrum of disease ranging from “simple steatosis”, which is considered relatively benign, to nonalcoholic ...
Effect of resveratrol on alcohol-induced mortality and liver lesions in mice
(BioMed Central, 2006-11-14)
Background
Resveratrol is a polyphenol with important antiinflammatory and antioxidant properties. We investigated the effect of resveratrol on alcohol-induced mortality and liver lesions in mice.
Methods
Mice were ...
Pravastatin inhibits cell proliferation and increased MAT1A expression in hepatocarcinoma cells and in vivo models
(BioMed Central, 2012-02-21)
Background: Statins may have therapeutic effects on hepatocarcinoma (HCC). This type of disorder is the most common malignant primary tumour in the liver. Our objective was to determine whether pravastatin had a therapeutic ...
Genetic Variants Associated with Colorectal Adenoma Susceptibility
(PUBLIC LIBRARY SCIENCE, 2016-04-14)
Background
Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk.
Aim
To determine if these genetic variants are associated also with adenoma susceptibility and may ...
Evaluation of Alpha 1-Antitrypsin and the Levels of mRNA Expression of Matrix Metalloproteinase 7, Urokinase Type Plasminogen Activator Receptor and COX-2 for the Diagnosis of Colorectal Cancer
(Public Library of Science, 2013-01-02)
Background: Colorectal cancer (CRC) is the second most common cause of death from cancer in both men and women in the majority of developed countries. Molecular tests of blood could potentially provide this ideal screening ...
Pterostilbene Reduces Liver Steatosis and Modifies Hepatic Fatty Acid Profile in Obese Rats
(MDPI, 2019-04-26)
Excessive fat accumulation within the liver is known as "simple hepatic steatosis", which is the most benign form of non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to determine whether pterostilbene ...
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms
(BMJ Publishing Group, 2021-06-07)
[EN] Objective Hepatocellular carcinoma (HCC) is a prevalent
and aggressive cancer usually arising on a background
of chronic liver injury involving inflammatory and hepatic
regenerative processes. The triggering receptor ...
TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation
(Elsevier, 2022-10)
Background & Aims: Inflammation, particularly that mediated by bacterial components translocating from the gut to the liver and binding to toll-like receptors (TLRs), is central to cholestatic liver injury. The triggering ...
Novel equation to determine the hepatic triglyceride concentration in humans by MRI: diagnosis and monitoring of NAFLD in obese patients before and after bariatric surgery
(Biomed Central, 2014-08-26)
Background: Non-alcoholic fatty liver disease (NAFLD) is caused by abnormal accumulation of lipids within liver cells. Its prevalence is increasing in developed countries in association with obesity, and it represents a ...