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The Activation of Prothrombin Seems to Play an Earlier Role than the Complement System in the Progression of Colorectal Cancer: A Mass Spectrometry Evaluation
(MDPI, 2020-12-11)
Colorectal cancer (CRC) is the second cause of death in men and the third in women. This work deals with the study of the low molecular weight protein fraction of sera from patients who underwent surgery for CRC and who ...
Soluble PD-L1 Is an Independent Prognostic Factor in Clear Cell Renal Cell Carcinoma
(MDPI, 2021-02-07)
(1). Background: Immunohistochemical (IHC) evaluation of programmed death-1 (PD-1) and its ligand (PD-L1) is being used to evaluate advanced malignancies with potential response to immune checkpoint inhibitors. We evaluated ...
Clinical Implications of (Pro)renin Receptor (PRR) Expression in Renal Tumours
(MDPI, 2021-02-10)
(1) Background: Renal cancer is one of the most frequent malignancies in Western countries, with an unpredictable clinical outcome, partly due to its high heterogeneity and the scarcity of reliable biomarkers of tumour ...
Altered Tissue and Plasma Levels of Fibroblast Activation Protein-α (FAP) in Renal Tumours
(MDPI, 2020-10-16)
(1) Background: Renal cell carcinoma (RCC) is a heterogeneous and complex disease with only partial response to therapy, high incidence of metastasis and recurrences, and scarce reliable biomarkers indicative of progression ...
An Integrative Omics Approach Reveals Involvement of BRCA1 in Hepatic Metastatic Progression of Colorectal Cancer
(MDPI, 2020-08-22)
(1) Background & Aims: The roles of different cells in the tumor microenvironment (TME) are critical to the metastatic process. The phenotypic transformation of the liver cells is one of the most important stages of the ...
Serum Sestrin-1 Concentration Is Higher in Frail than Non-Frail Older People Living in Nursing Homes
(MDPI, 2022-01-19)
Given the increasing prevalence of frailty and its implications for public health, the identification of biomarkers to detect frailty is essential. Sestrin-1 is a protein with a protective role in muscle function. This ...
Successful breastfeeding among women with intention to breastfeed: From physiology to socio-cultural factors
(Elsevier, 2022-01)
[EN] Background: Even if women have intention to breastfeed, they do not always achieve a successful breastfeeding. Aim: This study aims to analyse factors affecting breastfeeding prevalence among mothers that intended to ...
Low Serum Klotho Concentration is Associated with Worse Cognition, Psychological Components of Frailty, Dependence, and Falls in Nursing Home Residents
(Springer, 2021-04-27)
Serum alpha-klotho (s-klotho) protein has been linked with lifespan, and low concentrations of s-klotho have been associated with worse physical and cognitive outcomes. Although its significance in aging remains unclear, ...
SPANX-A/D protein subfamily plays a key role in nuclear organisation, metabolism and flagellar motility of human spermatozoa
(Nature Publishing Group, 2020-03-27)
Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes encode a protein family (SPANX-A, -B, -C and -D), whose expression is limited to the testis and spermatozoa in normal tissues and to a wide ...
Morphine leads to global genome changes in H3K27me3 levels via a Polycomb Repressive Complex 2 (PRC2) self-regulatory mechanism in mESCs
(BioMed Central, 2020-11-09)
Background: Environmentally induced epigenetic changes can lead to health problems or disease, but the mechanisms involved remain unclear. Morphine can pass through the placental barrier leading to abnormal embryo development. ...