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The MAPT H1 Haplotype Is a Risk Factor for Alzheimer’s Disease in APOE ε4 Non-carriers

GR@ACE Study Group; DEGESCO Consortium; López de Munain Arregui, Adolfo José; Martínez de Pancorbo Gómez, María de los Angeles (Frontiers Media, 2019-12-04)

An ancestral inversion of 900 kb on chromosome 17q21, which includes the microtubule-associated protein tau (MAPT) gene, defines two haplotype clades in Caucasians (H1 and H2). The H1 haplotype has been linked inconsistently ...

Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project

GRACE Consortium; DEGESCO Consortium; Alzheimers Dis Neuroimaging Initia; GRACE Study Grp; Martínez de Pancorbo Gómez, María de los Angeles; López de Munain Arregui, Adolfo José (Elsevier Science INC, 2019-10)

Introduction: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. Methods: Genome Research at Fundacio ACE (GR@ACE) is a ...