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Brønsted Base Catalyzed One-Pot Synthesis od Stereodefined Six-Member Carbocycles Featuring Transient Trienolates and a Key Intramolecular 1,6-Addition
(Wiley-VCH, 2019-07-31)
Acatalyst-driven one-pot reaction sequence is
developed for the enantio- and diastereoselective synthesis of
tetrasubstituted cyclohexenes from simple unsaturated ketones
or thioesters.The method involves atertiary ...
alpha-Branched Ketone Dienolates: Base-Catalyzed Generation and Regio- and Enantioselective Addition Reactions
(Wiley-VCH, 2019-05-14)
In this study, the unique capacity of bifunctional Brønsted bases to generate α-branched ketone dienolates and control both site- and stereoselectivity of their addition reactions to representative classes of carbon ...
1H-Imidazol-4(5H)-ones and thiazol-4(5H)-ones as emerging pronucleophiles in asymmetric catalysis
(Beilstein Institut, 2016-05-09)
Asymmetric catalysis represents a very powerful tool for the synthesis of enantiopure compounds. In this context the main focus has been directed not only to the search for new efficient chiral catalysts, but also to the ...
Catalytic Enantioselective Synthesis of Tertiary Thiols From 5H-Thiazol-4-ones and Nitroolefins: Bifunctional Ureidopeptide-Based Brønsted Base Catalysis
(WILEY-VCH Verlag, 2013-09-17)
The direct catalytic reaction between an enolizable carbonyl compound and an electrophile under proton-transfer conditions has emerged as a challenging versatile transformation in organic synthesis.1 Over the last years ...
Enantioselective Construction of Tetrasubstituted Stereogenic Carbons through Brønsted Base Catalyzed Michael Reactions: α´-Hydroxy Enones as Key Enoate Equivalent
(ACS, 2014-11-25)
Catalytic and asymmetric Michael reactions constitute very powerful tools for the construction of new C–C bonds in synthesis, but most of the reports claiming high selectivity are limited to some specific combinations of ...
α-Hydroxy Ketones as Masked Ester Donors in Brønsted Base-Catalyzed Conjugate Additions to Nitroalkenes
(ChemPubSoc Europe, 2018-02-15)
Enantioselective Addition of Alkynyl Ketones to Nitroolefins Assisted by Bronsted Base/H-Bonding Catalysis
(Wiley, 2019-03-21)
Various sets of enolizable alkynyl ketones (including methyl ynones with α-aryl, α-alkenyl, and α-alkoxy groups) were able to react smoothly with nitroolefins with the assistance of bifunctional Brønsted base/H-bond catalysts ...
Probing α‐Amino Aldehydes as Weakly Acidic Pronucleophiles: Direct Access to Quaternary α‐Amino Aldehydes by an Enantioselective Michael Addition Catalyzed by Brønsted Bases
(Wiley, 2020-10-09)
The high tendency of α-amino aldehydes to undergo 1,2-additions and their relatively low stability under basic conditions have largely prevented their use as pronucleophiles in the realm of asymmetric catalysis, particularly ...
β2, 2-Amino Acid N-Carboxyanhydrides Relying on Sequential Enantioselective C(4)-Functionalization of Pyrrolidin-2,3-diones and Regioselective Baeyer–Villiger Oxidation
(Wiley, 2017-02-28)
A catalytic enantioselective entry to β2, 2-amino acids enabling their direct coupling with nucleophiles is described. The approach is based upon an effective bifunctional Brønsted base catalyzed construction of a quaternary ...