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Now showing items 111-120 of 155
Topical Administration of SLN-Based Gene Therapy for the Treatment of Corneal Inflammation by De Novo IL-10 Production
(MDPI, 2020-06-23)
One of the main challenges in gene therapy is the issue of delivery, and it is especially relevant for the success of gene therapy in the cornea. In the present work, eye drops containing biocompatible non-viral vectors ...
Nanomedicines to Deliver mRNA: State of the Art and Future Perspectives
(MDPI, 2020-02-20)
The use of messenger RNA (mRNA) in gene therapy is increasing in recent years, due to its unique features compared to plasmid DNA: Transient expression, no need to enter into the nucleus and no risk of insertional mutagenesis. ...
Niosome-Based Approach for In Situ Gene Delivery to Retina and Brain Cortex as Immune-Privileged Tissues
(MDPI, 2020-02-25)
Non-viral vectors have emerged as a promising alternative to viral gene delivery systems due to their safer profile. Among non-viral vectors, recently, niosomes have shown favorable properties for gene delivery, including ...
MMP-9 Downregulation with Lipid Nanoparticles for Inhibiting Corneal Neovascularization by Gene Silencing
(MDPI, 2019-04-18)
Gene silencing targeting proangiogenic factors have been shown to be a useful strategy in the treatment of corneal neovascularization (CNV). Among interference RNA (RNAi) molecules, short-hairpin RNA (shRNA) is a plasmid-coded ...
Determinants of Participation in a Post-Hospitalization Physical Exercise Program for Older Adults
(BioMed Central, 2020-10-16)
Background: Older patients often experience a decline in physical function and cognitive status after hospitalization. Although interventions involving physical exercise are effective in improving functional performance, ...
FODMAP Intake in Spanish Population: Open Approach for Risk Assessment
(MDPI, 2020-08-13)
Fermentable oligo-, di- and monosaccharides and polyols’ (FODMAP) were related with intestinal complications. The present study aimed to determine the FODMAP consumption of Spanish children, adolescents and adults, analyzing ...
The key role of ovalbumin in lipid bioaccessibility and oxidation product profile during the in vitro digestion of slightly oxidized soybean oil
(Royal Society of Chemistry, 2019-06-25)
The behaviour of slightly oxidized virgin and refined soybean oils during in vitro digestion was studied by H-1 nuclear magnetic resonance (H-1 NMR) and solid phase microextraction-gas chromatography/mass spectrometry. The ...
Relación entre el índice de consumo de pescado y carne y la adecuación y calidad de la dieta en mujeres jóvenes universitarias
(Sociedad Española de Nutrición Parental y Enteral, 2014)
[ES] Introducción: En las poblaciones occidentales el consumo de pescado es menor que el de carnes y esto puede influir en la calidad de la dieta total.
Objetivo: Comprobar si la relación entre el consumo de pescado y ...
A Dual Perspective of the Action of Lysine on Soybean Oil Oxidation Process Obtained by Combining H-1 NMR and LC-MS: Antioxidant Effect and Generation of Lysine-Aldehyde Adducts
(MDPI, 2019-08-21)
Little is still known about both the effect of amino acids on the oxidation course of edible oils and the modifications that the former may undergo during this process. Bearing this in mind, the objective of this work was ...
Complexity and Uniqueness of the Aromatic Profile of Smoked and Unsmoked Herreno Cheese
(MDPI, 2014-06)
In this work, the volatile fraction of unsmoked and smoked Herreno cheese, a type of soft cheese from the Canary Islands, has been characterized for the first time. In order to evaluate if the position in the smokehouse ...