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Now showing items 2711-2720 of 11006
Políticas sobre la integración de las TIC en la escuela de la Comunidad Autónoma del País Vasco
(Universidad de Extremadura, 2011)
[ES]En la Comunidad Autónoma Vasca se han tomado una serie de decisiones estratégicas materializadas en diversas políticas, planes institucionales e iniciativas con el objeto de integrar, usar e innovar con TIC en las ...
USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy
(Biomed Central, 2013)
Reversible protein ubiquitination is emerging as a key process for maintaining cell homeostasis, and the enzymes that participate in this process, in particular E3 ubiquitin ligases and deubiquitinases (DUBs), are increasingly ...
Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage
(Biomed Central, 2015-02-06)
Background: In complex with its cofactor UAF1, the USP1 deubiquitinase plays an important role in cellular processes related to cancer, including the response to DNA damage. The USP1/UAF1 complex is emerging as a novel ...
Fomentando la reflexión sobre la atención a la diversidad. Estudios de caso en Chile
(2008)
Desde 1990 el Ministerio de Educación de Chile ha trabajado por el desarrollo de un sistema educativo que responda a la diversidad dentro de un contexto caracterizado por una cultura jerárquica y unas prácticas tradicionales. ...
Using reflective processes to promote attention to diversity in schools: a studv of practice in Chile
(2008)
[EN] Over the last decade or so, many writers have argued that inclusive practices are more likely to be developed when school communities are involved in collaborative processes of inquiry, reflection and action in order ...
Las casas-torre bajomedievales. Análisis sistémico de un proceso de reestructuración espacial/territorial
(CSIC; UPV/EHU, 2004)
[ES] La torre banderiza es uno de los más relevantes elementos del patrimonio construido vasco. Diseminados por toda la geografía de la comunidad autónoma, se pueden encontrar ejemplos representativos de este tipo ...
Two Nuclear Localization Signals in USP1 Mediate Nuclear Import of the USP1/UAF1 Complex
(Public Library of Science, 2012-06-06)
The human deubiquitinase USP1 plays important roles in cancer-related processes, such as the DNA damage response, and the maintenance of the undifferentiated state of osteosarcoma cells. USP1 deubiquitinase activity is ...
In Vitro Surfactant and Perfluorocarbon Aerosol Deposition in a Neonatal Physical Model of the Upper Conducting Airways
(Public Library Science, 2014-09-11)
Objective: Aerosol delivery holds potential to release surfactant or perfluorocarbon (PFC) to the lungs of neonates with respiratory distress syndrome with minimal airway manipulation. Nevertheless, lung deposition in ...
Improved Mechanical Properties of Compatibilized Polypropylene/Polyamide-12 Blends
(Hindawi Publishing Corporation, 2015)
Compatibilized blends of polypropylene (PP) and polyamide-12 (PA12) as a second component were obtained by direct injection molding having first added 20% maleic anhydride-modified copolymer (PP-g-MA) to the PP, which ...
Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness
(Public Library Science, 2015-07-07)
Lymphangioleiomyomatosis (LAM) is a rare lung-metastasizing neoplasm caused by the proliferation of smooth muscle-like cells that commonly carry loss-of-function mutations in either the tuberous sclerosis complex 1 or 2 ...