Now showing items 2831-2840 of 3395
Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases
Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators of many key cellular events such as proliferation, differentiation, cell cycle regulation, migration, or apoptosis. To control these ...
Expansion of Human Limbal Epithelial Stem/Progenitor Cells Using Different Human Sera: A Multivariate Statistical Analysis
Transplantation of human cultured limbal epithelial stem/progenitor cells (LESCs) has demonstrated to restore the integrity and functionality of the corneal surface in about 76% of patients with limbal stem cell deficiency. ...
Using a Simple Cellular Assay to Map NES Motifs in Cancer-Related Proteins, Gain Insight into CRM1-Mediated NES Export, and Search for NES-Harboring Micropeptides
The nuclear export receptor CRM1 (XPO1) recognizes and binds specific sequence motifs termed nuclear export signals (NESs) in cargo proteins. About 200 NES motifs have been identified, but over a thousand human proteins ...
Medicina personalizada, algoritmos predictivos y utilización de sistemas de decisión automatizados en asistencia sanitaria. Problemas éticos
(Instituto de Filosofía, CCHS, CSIC, 2019-05-31)
[ES] Vivimos lo que ya es el nacimiento de una nueva era, marcada por el desarrollo de las nuevas herramientas de Inteligencia Artificial, los denominados sistemas de machine learning, basados en algoritmos capaces de ...
Pimavanserin exhibits serotonin 5-HT 2A receptor inverse agonism for G αi1 - and neutral antagonism for G αq/11 -proteins in human brain cortex
[EN] Pimavanserin is claimed as the first antipsychotic drug that shows selectivity for serotonin 5- HT 2 receptors (5-HT 2 Rs) and lacks of affinity for dopamine D 2 receptors (D 2 Rs). Cell-based func- tional assays ...
Activating hidden metrological usefulness
(American Physical Society, 2020-07-07)
[EN] We consider bipartite entangled states that cannot outperform separable states in any linear interferometer. Then, we show that these states can still be more useful metrologically than separable states if several ...
What can we expect from the EU legal framework in a pandemic outbreak?
(University of Trento, 2020-06)
The arrival of a new form of coronavirus at the end of 2019 and its subsequent expansion to multiple countries has already caused severe consequences whose final extent we are unfortunately still far from seeing. In our ...
Health Information Counselors Help Avoid Automatized Decisions in Health Care
(Wolters Kluwer, 2019-05)
Ionic Polyureas—A Novel Subclass of Poly(Ionic Liquid)s for CO2 Capture
The growing concern for climate change and global warming has given rise to investigations in various research fields, including one particular area dedicated to the creation of solid sorbents for efficient CO2 capture. ...
An Intelligent System-on-a-Chip for a Real-Time Assessment of Fuel Consumption to Promote Eco-Driving
Pollution that originates from automobiles is a concern in the current world, not only because of global warming, but also due to the harmful effects on people’s health and lives. Despite regulations on exhaust gas emissions ...