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Significance of Simple Steatosis: An Update on the Clinical and Molecular Evidence
(MDPI, 2020-11-11)
Non-alcoholic fatty liver disease (NAFLD) is defined clinicopathologically by the accumulation of lipids in >5% of hepatocytes and the exclusion of secondary causes of fat accumulation. NAFLD encompasses a wide spectrum ...
A Review of the Epidemiology, Pathophysiology, and Efficacy of Anti-diabetic Drugs Used in the Treatment of Nonalcoholic Fatty Liver Disease
(Springer, 2021-08-19)
In recent years, epidemiological studies have consistently demonstrated that the coexistence of nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) is strongly associated with increased mortality ...
Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)
(MDPI, 2021-09-22)
Objectives: Lately, many countries have restricted or even banned transfat, and palm oil has become a preferred replacement for food manufacturers. Whether palm oil is potentially an unhealthy food mainly due to its high ...
Nobiletin Enhances the Development and Quality of Bovine Embryos In Vitro During Two Key Periods of Embryonic Genome Activation
(Nature, 2021-06-03)
In vitro culture can alter the development and quality of bovine embryos. Therefore, we aimed to evaluate whether nobiletin supplementation during EGA improves embryonic development and blastocyst quality and if it affects ...
Non-Invasive Risk Stratification in NAFLD/NASH Patients for Screening EGD
(Dove Medical Press, 2022-01-10)
Phosphorylation and Stabilization of PIN1 by JNK Promote Intrahepatic Cholangiocarcinoma Growth
(American Association for the Study of Liver Diseases, 2021-11)
Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive type of liver cancer in urgent need of treatment options. Aberrant activation of the c-Jun N-terminal kinase (JNK) pathway is a key feature ...
Serum Thioredoxin-80 is associated with age, ApoE4, and neuropathological biomarkers in Alzheimer’s disease: a potential early sign of AD
(BMC, 2022)
[EN] Background: Thioredoxin-80 (Trx80) is a cleavage product from the redox-active protein Thioredoxin-1 and has been previously described as a pro-inflammatory cytokine secreted by immune cells. Previous studies in our ...
Liver metastases of intrahepatic Cholangiocarcinoma: implications for an updated staging system
(Wiley, 2021-06-18)
[EN] BACKGROUND AND AIMS: Intrahepatic cholangiocarcinoma
(iCCA) with liver metastases is perceived to have a
poor prognosis, but the American Joint Committee on Cancer
(AJCC) classifies them as early stage in the absence ...
A Three-Protein Panel to Support the Diagnosis of Sepsis in Children
(MDPI, 2022-03-12)
Sepsis is a syndrome without a standard validated diagnostic test. Early recognition is crucial. Serum proteome analysis in children with sepsis may identify new biomarkers. This study aimed to find suitable blood biomarkers ...
The effectiveness of a basic exercise intervention to improve strength and balance in women with osteoporosis
(Dove Medical Press, 2017-03-14)
Objective: To determine the effects of a simple exercise program on the balance and strength of postmenopausal women with osteoporosis.
Methods: This program was based on low intensity strength and balance exercises, ...